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AmiGO 2: Term Details for "DNA-binding transcription factor activity" (GO:0003700)

  • ️Gene Ontology Consortium
Accession
GO:0003700
Name
DNA-binding transcription factor activity
Ontology
molecular_function
Synonyms
DNA binding transcription factor activity, gene-specific transcription factor activity, sequence-specific DNA binding transcription factor activity, bacterial-type DNA binding transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity, bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding, bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding, metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding transcription factor activity, sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity, transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding, transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding, transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding, transcription factor activity, metal ion regulated sequence-specific DNA binding, nucleic acid binding transcription factor activity, transcription factor activity
Alternate IDs
GO:0001071, GO:0001204, GO:0001199, GO:0001131, GO:0000130, GO:0001151, GO:0001130
Definition
A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. Source: GOC:txnOH-2018
Comment
Usage guidance: Most DNA-binding transcription factors do not have enzymatic activity. The presence of specific DNA-binding domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase) and no known DNA binding domain, consider annotating to GO:0003712 transcription coregulator activity. Special care should be taken with proteins containing zinc fingers, Myb/SANT and ARID domains, since only a subset of proteins containing these domains directly and selectively bind to regulatory DNA motifs in cis-regulatory regions.
History
See term history for GO:0003700 at QuickGO
Chem. react.
None
Subset
goslim_metagenomics
goslim_chembl
goslim_drosophila
goslim_plant
goslim_mouse
goslim_agr
goslim_candida
goslim_yeast
Link to all genes and gene products annotated to DNA-binding transcription factor activity (excluding "regulates").
Link to all direct and indirect annotations to DNA-binding transcription factor activity (excluding "regulates").
Link to all direct and indirect annotations download (limited to first 10,000) for DNA-binding transcription factor activity (excluding "regulates").