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AmiGO 2: Term Details for "TSC1-TSC2 complex" (GO:0033596)

️Gene Ontology Consortium

Accession

GO:0033596

Name

TSC1-TSC2 complex

Ontology

cellular_component

Synonyms

tuberin-hamartin complex, tuberous sclerosis complex

Alternate IDs

None

Definition

A protein complex consisting of at least tumerin and hamartin; its formation may regulate hamartin homomultimer formation. The complex acts as a GTPase activating protein (GAP) for the small GTPase (Rheb), and inhibits the TOR signaling pathway. Source: PMID:9580671, PMID:17121544, PMID:10585443

Comment

None

History

See term history for GO:0033596 at QuickGO

Chem. react.

None

Subset

None

Link to all genes and gene products annotated to TSC1-TSC2 complex (excluding "regulates").

Link to all direct and indirect annotations to TSC1-TSC2 complex (excluding "regulates").

Link to all direct and indirect annotations download (limited to first 10,000) for TSC1-TSC2 complex (excluding "regulates").