AmiGO 2: Term Details for "IRE1-mediated unfolded protein response" (GO:0036498)
️Gene Ontology Consortium
️Tue Nov 05 2024
Accession
GO:0036498
Name
IRE1-mediated unfolded protein response
Ontology
biological_process
Synonyms
IRE1 branch of UPR, UPR signaling by IRE1 stress sensor, endoplasmic reticulum unfolded protein response; IRE1 signaling, ERN1-mediated unfolded protein response, IRE1 signaling in response to endoplasmic reticulum stress, inositol-requiring enzyme 1-mediated unfolded protein response, inositol-requiring transmembrane kinase/endonuclease signal transduction, IRE1alpha unfolded protein response, IRE1p unfolded protein response, IRE1 signal transduction pathway
Alternate IDs
None
Definition
The series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.
Source:
GOC:PARL,
PMID:22013210,
GOC:bf
Comment
Consider also annotating to 'eiF2alpha phosphorylation in response to endoplasmic reticulum stress ; GO:0036492' or its descendants.