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SUMO4 - Wikipedia

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SUMO4

Identifiers

SUMO4, IDDM5, SMT3H4, SUMO-4, dJ281H8.4, small ubiquitin-like modifier 4, small ubiquitin like modifier 4

External IDs

OMIM: 608829; HomoloGene: 88399; GeneCards: SUMO4; OMA:SUMO4 - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6q25.1	Start	149,400,262 bp^[1]
End	149,401,278 bp^[1]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

oocyte

buccal mucosa cell

lactiferous duct

pylorus

renal medulla

optic nerve

cardia

mucosa of pharynx

superior surface of tongue

vena cava

n/a

More reference expression data

BioGPS

More reference expression data

Gene ontology
Molecular function	protein tag ubiquitin-like protein ligase binding
Cellular component	nucleus
Biological process	protein sumoylation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


387082


n/a

Ensembl


ENSG00000177688


n/a

UniProt


Q6EEV6


n/a

RefSeq (mRNA)


NM_001002255


n/a

RefSeq (protein)


NP_001002255


n/a

Location (UCSC)

Chr 6: 149.4 – 149.4 Mb

n/a

PubMed search

^[2]

n/a

Wikidata

View/Edit Human

Small ubiquitin-related modifier 4 is a protein that in humans is encoded by the SUMO4 gene.^[3]^[4]

This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins' subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism.^[4]

SUMO4 has been shown to interact with IκBα.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177688 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bohren KM, Nadkarni V, Song JH, Gabbay KH, Owerbach D (Jun 2004). "A M55V polymorphism in a novel SUMO gene (SUMO-4) differentially activates heat shock transcription factors and is associated with susceptibility to type I diabetes mellitus". The Journal of Biological Chemistry. 279 (26): 27233–8. doi:10.1074/jbc.M402273200. PMID 15123604.
^ ^a ^b "Entrez Gene: SUMO4 SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae)".
^ Guo D, Li M, Zhang Y, Yang P, Eckenrode S, Hopkins D, Zheng W, Purohit S, Podolsky RH, Muir A, Wang J, Dong Z, Brusko T, Atkinson M, Pozzilli P, Zeidler A, Raffel LJ, Jacob CO, Park Y, Serrano-Rios M, Larrad MT, Zhang Z, Garchon HJ, Bach JF, Rotter JI, She JX, Wang CY (Aug 2004). "A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes". Nature Genetics. 36 (8): 837–41. doi:10.1038/ng1391. PMID 15247916. S2CID 41123857.

Wang CY, Podolsky R, She JX (Oct 2006). "Genetic and functional evidence supporting SUMO4 as a type 1 diabetes susceptibility gene". Annals of the New York Academy of Sciences. 1079 (1): 257–67. Bibcode:2006NYASA1079..257W. doi:10.1196/annals.1375.039. PMID 17130563. S2CID 20462827.
Davies JL, Kawaguchi Y, Bennett ST, Copeman JB, Cordell HJ, Pritchard LE, Reed PW, Gough SC, Jenkins SC, Palmer SM (Sep 1994). "A genome-wide search for human type 1 diabetes susceptibility genes". Nature. 371 (6493): 130–6. Bibcode:1994Natur.371..130D. doi:10.1038/371130a0. PMID 8072542. S2CID 4275341.
Luo DF, Buzzetti R, Rotter JI, Maclaren NK, Raffel LJ, Nisticò L, Giovannini C, Pozzilli P, Thomson G, She JX (May 1996). "Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8". Human Molecular Genetics. 5 (5): 693–8. doi:10.1093/hmg/5.5.693. PMID 8733139.
Mungall AJ, Palmer SA, Sims SK, Edwards CA, Ashurst JL, Wilming L, Jones MC, Horton R, Hunt SE, Scott CE, Gilbert JG, Clamp ME, Bethel G, Milne S, Ainscough R, Almeida JP, Ambrose KD, Andrews TD, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beare DM, Beasley H, Beasley O, Bird CP, Blakey S, Bray-Allen S, Brook J, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Clark SY, Clark G, Clee CM, Clegg S, Cobley V, Collier RE, Collins JE, Colman LK, Corby NR, Coville GJ, Culley KM, Dhami P, Davies J, Dunn M, Earthrowl ME, Ellington AE, Evans KA, Faulkner L, Francis MD, Frankish A, Frankland J, French L, Garner P, Garnett J, Ghori MJ, Gilby LM, Gillson CJ, Glithero RJ, Grafham DV, Grant M, Gribble S, Griffiths C, Griffiths M, Hall R, Halls KS, Hammond S, Harley JL, Hart EA, Heath PD, Heathcott R, Holmes SJ, Howden PJ, Howe KL, Howell GR, Huckle E, Humphray SJ, Humphries MD, Hunt AR, Johnson CM, Joy AA, Kay M, Keenan SJ, Kimberley AM, King A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd CR, Lloyd DM, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, Maslen GL, Matthews L, McCann OT, McLaren SJ, McLay K, McMurray A, Moore MJ, Mullikin JC, Niblett D, Nickerson T, Novik KL, Oliver K, Overton-Larty EK, Parker A, Patel R, Pearce AV, Peck AI, Phillimore B, Phillips S, Plumb RW, Porter KM, Ramsey Y, Ranby SA, Rice CM, Ross MT, Searle SM, Sehra HK, Sheridan E, Skuce CD, Smith S, Smith M, Spraggon L, Squares SL, Steward CA, Sycamore N, Tamlyn-Hall G, Tester J, Theaker AJ, Thomas DW, Thorpe A, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, White SS, Whitehead SL, Whittaker H, Wild A, Willey DJ, Wilmer TE, Wood JM, Wray PW, Wyatt JC, Young L, Younger RM, Bentley DR, Coulson A, Durbin R, Hubbard T, Sulston JE, Dunham I, Rogers J, Beck S (Oct 2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Guo D, Li M, Zhang Y, Yang P, Eckenrode S, Hopkins D, Zheng W, Purohit S, Podolsky RH, Muir A, Wang J, Dong Z, Brusko T, Atkinson M, Pozzilli P, Zeidler A, Raffel LJ, Jacob CO, Park Y, Serrano-Rios M, Larrad MT, Zhang Z, Garchon HJ, Bach JF, Rotter JI, She JX, Wang CY (Aug 2004). "A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes". Nature Genetics. 36 (8): 837–41. doi:10.1038/ng1391. PMID 15247916. S2CID 41123857.
Smyth DJ, Howson JM, Lowe CE, Walker NM, Lam AC, Nutland S, Hutchings J, Tuomilehto-Wolf E, Tuomilehto J, Guja C, Ionescu-Tîrgoviste C, Undlien DE, Rønningen KS, Savage D, Dunger DB, Twells RC, McArdle WL, Strachan DP, Todd JA (Feb 2005). "Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes". Nature Genetics. 37 (2): 110–1, author reply 112–3. doi:10.1038/ng0205-110. PMID 15678134. S2CID 33336557.
Qu H, Bharaj B, Liu XQ, Curtis JA, Newhook LA, Paterson AD, Hudson TJ, Polychronakos C (Feb 2005). "Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes". Nature Genetics. 37 (2): 111–2, author reply 112–3. doi:10.1038/ng0205-111. PMID 15678135.
Park Y, Park S, Kang J, Yang S, Kim D (Feb 2005). "Assessing the validity of the association between the SUMO4 M55V variant and risk of type 1 diabetes". Nature Genetics. 37 (2): 112, author reply 112–3. doi:10.1038/ng0205-112a. PMID 15678137. S2CID 30406915.
Owerbach D, McKay EM, Yeh ET, Gabbay KH, Bohren KM (Nov 2005). "A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation". Biochemical and Biophysical Research Communications. 337 (2): 517–20. doi:10.1016/j.bbrc.2005.09.090. PMID 16198310.
Guo D, Han J, Adam BL, Colburn NH, Wang MH, Dong Z, Eizirik DL, She JX, Wang CY (Dec 2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress". Biochemical and Biophysical Research Communications. 337 (4): 1308–18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.
Noso S, Ikegami H, Fujisawa T, Kawabata Y, Asano K, Hiromine Y, Tsurumaru M, Sugihara S, Lee I, Kawasaki E, Awata T, Ogihara T (Dec 2005). "Genetic heterogeneity in association of the SUMO4 M55V variant with susceptibility to type 1 diabetes". Diabetes. 54 (12): 3582–6. doi:10.2337/diabetes.54.12.3582. PMID 16306380.
Tsurumaru M, Kawasaki E, Ida H, Migita K, Moriuchi A, Fukushima K, Fukushima T, Abiru N, Yamasaki H, Noso S, Ikegami H, Awata T, Sasaki H, Eguchi K (Aug 2006). "Evidence for the role of small ubiquitin-like modifier 4 as a general autoimmunity locus in the Japanese population". The Journal of Clinical Endocrinology and Metabolism. 91 (8): 3138–43. doi:10.1210/jc.2006-0206. PMID 16735488.
Costas J, Perez-Pampin E, Ferreiros-Vidal I, Torres M, Phillips C, Vicario JL, Pablos JL, Carracedo A, Gomez-Reino JJ, Gonzalez A (Jun 2006). "SUMO4 and MAP3K7IP2 single nucleotide polymorphisms and susceptibility to rheumatoid arthritis". The Journal of Rheumatology. 33 (6): 1048–51. PMID 16755651.
Sedimbi SK, Shastry A, Park Y, Rumba I, Sanjeevi CB (Oct 2006). "Association of SUMO4 M55V polymorphism with autoimmune diabetes in Latvian patients". Annals of the New York Academy of Sciences. 1079 (1): 273–7. Bibcode:2006NYASA1079..273S. doi:10.1196/annals.1375.041. PMID 17130565. S2CID 22345614.
Lin HY, Wang CL, Hsiao PJ, Lu YC, Chen SY, Lin KD, Hsin SC, Hsieh MC, Shin SJ (Apr 2007). "SUMO4 M55V variant is associated with diabetic nephropathy in type 2 diabetes". Diabetes. 56 (4): 1177–80. doi:10.2337/db06-1283. PMID 17229939.
Sedimbi SK, Kanungo A, Shastry A, Park Y, Sanjeevi CB (Apr 2007). "No association of SUMO4 M55V with autoimmune diabetes in Asian-Indian patients". International Journal of Immunogenetics. 34 (2): 137–42. doi:10.1111/j.1744-313X.2007.00668.x. PMID 17373940. S2CID 10433791.
Noso S, Fujisawa T, Kawabata Y, Asano K, Hiromine Y, Fukai A, Ogihara T, Ikegami H (Jun 2007). "Association of small ubiquitin-like modifier 4 (SUMO4) variant, located in IDDM5 locus, with type 2 diabetes in the Japanese population". The Journal of Clinical Endocrinology and Metabolism. 92 (6): 2358–62. doi:10.1210/jc.2007-0031. PMID 17374705.
Bohren KM, Gabbay KH, Owerbach D (Aug 2007). "Affinity chromatography of native SUMO proteins using His-tagged recombinant UBC9 bound to Co2+-charged talon resin". Protein Expression and Purification. 54 (2): 289–94. doi:10.1016/j.pep.2007.03.013. PMID 17459725.