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History
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JPS63269301A - Transfer method - Google Patents
PURPOSE:To prevent the immersion of bubble to ultraviolet curing resin from occurring and to realize the mass production of a disk, by curving a substrate, and pressurizing the substrate contact with a roll so as to be pressed on a stamper keeping a curved state. CONSTITUTION:Since the end part of the substrate 2 on a downstream side is pressed downward by descending the arm 10 of a pressing mechanism 9, the end part on the downstream side is separated from the stamper 1, and the substrate 2 is curved in a circular arc shape by elasticity. Next, a pressurizing roller 12 is moved horizontally in the direction of the downstream, and is connected rotatably so as to press the lower plane of the substrate 2 on the stamper 1. Also, since the pressing mechanism 9 is ascended gradually as pressing the substrate 2 downward following the movement of the pressuring roller 12, the substrate 2 is pressed on the lower plane of the stamper 1 keeping the curved state. And the ultraviolet curing resin on an upper plane bites at the stamper 1, and next, an ultraviolet ray illuminator 14 advances underneath the substrate 2. In such a way, the invasion of the air in the ultraviolet curing resin can be prevented from occurring, and signal noise due to the bubble is eliminated, then, continuous transfer can be performed and a method suitable for the mass production can be realized.
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CA2618163A1 - Head and neck cancer biomarkers - Google Patents
Methods for detecting head and neck cancer or a related disease condition in a subject are described comprising measuring head and neck cancer markers or polynucleotides encoding the markers in a sample from the subject. The invention also provides localization or imaging methods for head and neck cancers and kits for carrying out the methods of the invention. The invention also contemplates therapeutic applications for head and neck cancers employing head and neck cancer markers, polynucleotides encoding the markers, and/or binding agents for the markers.