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Lmo1 MGI Mouse Gene Detail - MGI:102812 - LIM domain only 1

Summary

Symbol

Lmo1
Name

LIM domain only 1
Synonyms

Rbtn-1, Rbtn1, Ttg1

Feature Type

protein coding gene
IDs

MGI:102812
NCBI Gene: 109594
Alliance
Transcription Start Sites

6 TSS

Location &
Maps

Sequence Map

Chr7:108737776-108774356 bp, - strand
From NCBI annotation of GRCm39
Genome Browsers

Genetic Map

Chromosome 7, 57.21 cM
Mapping Data

11 experiments

Strain
Comparison

SNPs within 2kb

947 from dbSNP Build 142
Strain Annotations

18
RFLP

Homology

Human Ortholog

LMO1, LIM domain only 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LMO1, LIM domain only 1
Synonyms

RBTN1, RHOM1, TTG1
Links
Chr Location

11p15.4; chr11:8224309-8268787 (-) GRCh38

MGI Vertebrate Homology
HCOP

vertebrate homology predictions: LMO1
Gene Tree

Mutations,
Alleles, and
Phenotypes

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Phenotype Summary

8 phenotypes from 3 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
16 phenotype references

Phenotype Overview

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles
Chemically induced (other)
Endonuclease-mediated
Radiation induced
Targeted
Genomic Mutations

2 involving Lmo1
Incidental Mutations
Find Mice (IMSR)
Comparison Matrix

Homozygous mutant mice show no overt phenotype.

Gene Ontology
(GO)
Classifications

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All GO Annotations
GO References

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

Expression

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Expression Overview

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results
Tissues
cDNA Data
Literature Summary

Other Mouse Links
Other Vertebrate Links

Sequences &
Gene Models

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All Sequences
RefSeq
UniProt
CCDS

Ensembl
NCBI Gene

Protein
Information

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UniProt

4 Sequences
Protein Ontology
InterPro Domains

IPR050945 LMO/RBTN Transcription Factors

Molecular
Reagents

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All nucleic 60

Genomic 5

Primer pair 10

Other 6

Microarray probesets 3

Other
Accession IDs

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MGD-MRK-13796, MGD-MRK-13799, MGD-MRK-19720

References

Summaries

Developmental Gene Expression 46

Gene Ontology 8

Phenotypes 16
Earliest

J:15547 McGuire EA, et al., The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein. Mol Cell Biol. 1989 May;9(5):2124-32
Latest

J:350460 Soussi G, et al., TBX3 is essential for establishment of the posterior boundary of anterior genes and upregulation of posterior genes together with HAND2 during the onset of limb bud development. Development. 2024 Jun 1;151(11)