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Mtnr1a MGI Mouse Gene Detail - MGI:102967 - melatonin receptor 1A

Summary

Symbol

Mtnr1a
Name

melatonin receptor 1A
Synonyms

Mel1a receptor, MelR

Feature Type

protein coding gene
IDs

MGI:102967
NCBI Gene: 17773
Alliance

Location &
Maps

Sequence Map

Chr8:45522174-45541543 bp, + strand
From Ensembl annotation of GRCm39
Genome Browsers

Genetic Map

Chromosome 8, 24.95 cM
Mapping Data

4 experiments

Strain
Comparison

SNPs within 2kb

790 from dbSNP Build 142
Strain Annotations

18

Homology

Human Ortholog

MTNR1A, melatonin receptor 1A

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MTNR1A, melatonin receptor 1A
Synonyms

MEL-1A-R, MT1
Links
Chr Location

4q35.2; chr4:186526792-186555567 (-) GRCh38

MGI Vertebrate Homology
HCOP

vertebrate homology predictions: MTNR1A
Gene Tree

Mutations,
Alleles, and
Phenotypes

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Phenotype Summary

8 phenotypes from 1 allele in 2 genetic backgrounds
39 phenotype references

Phenotype Overview

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles
Chemically induced (other)
Endonuclease-mediated
Targeted
Genomic Mutations

1 involving Mtnr1a
Incidental Mutations
Find Mice (IMSR)
Comparison Matrix

Mice homozygous for disruptions in this gene are essentially normal, with normal circadian functions. In vitro studies report the absence of inhibitory effects of melatonin on suprachiasma neuronal firing.

Gene Ontology
(GO)
Classifications

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All GO Annotations
GO References

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

Expression

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Expression Overview

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results
Tissues
cDNA Data
Literature Summary

Other Mouse Links
Other Vertebrate Links

Sequences &
Gene Models

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All Sequences
RefSeq
UniProt
CCDS

Ensembl
NCBI Gene

Protein
Information

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UniProt

4 Sequences
Protein Ontology
InterPro Domains

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

Molecular
Reagents

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All nucleic 14

Genomic 4

cDNA 6

Primer pair 3

Other 1

Microarray probesets 3

References

Summaries

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 39
Earliest

J:26189 Slaugenhaupt SA, et al., Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a). Genomics. 1995 May 20;27(2):355-7
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;