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Lbx1 MGI Mouse Gene Detail - MGI:104867 - ladybird homeobox 1

Summary

Symbol

Lbx1
Name

ladybird homeobox 1
Synonyms

Lbx1h

Feature Type

protein coding gene
IDs

MGI:104867
NCBI Gene: 16814
Alliance
Transcription Start Sites

1 TSS

Location &
Maps

Sequence Map

Chr19:45221123-45224251 bp, - strand
From Ensembl annotation of GRCm39
Genome Browsers

Genetic Map

Chromosome 19, 38.61 cM, cytoband D
Mapping Data

1 experiment

Strain
Comparison

SNPs within 2kb

115 from dbSNP Build 142
Strain Annotations

18

Homology

Human Ortholog

LBX1, ladybird homeobox 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LBX1, ladybird homeobox 1
Synonyms

CCHS3, homeobox, HPX-6, HPX6, LBX1H
Links
Chr Location

10q24.32; chr10:101226994-101229463 (-) GRCh38

MGI Vertebrate Homology
HCOP

vertebrate homology predictions: LBX1
Gene Tree

Human Diseases

Diseases

1 with human LBX1 associations

Mutations,
Alleles, and
Phenotypes

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Phenotype Summary

41 phenotypes from 5 alleles in 9 genetic backgrounds
9 phenotypes from multigenic genotypes
69 phenotype references

Phenotype Overview

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles
Endonuclease-mediated
Targeted
Genomic Mutations

3 involving Lbx1
Incidental Mutations
Find Mice (IMSR)
Comparison Matrix
Recombinase Activity

Homozygous null mice display impaired limb muscle development resulting from progenitor cell migration defects. Defects in heart development and nervous system morphology are also reported.

Gene Ontology
(GO)
Classifications

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All GO Annotations
GO References

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

Expression

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Expression Overview

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results
Tissues
cDNA Data
Literature Summary

Other Mouse Links
Other Vertebrate Links

Sequences &
Gene Models

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All Sequences
RefSeq
UniProt
CCDS

Ensembl
NCBI Gene

Protein
Information

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UniProt

1 Sequence
Protein Ontology
InterPro Domains

IPR009057 Homeobox-like domain superfamily

IPR051892 LBX Family Transcription Factors

Molecular
Reagents

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All nucleic 23

Genomic 8

Primer pair 2

Other 2

Microarray probesets 3

References

Summaries

Developmental Gene Expression 116

Gene Ontology 10

Phenotypes 69
Earliest

J:29933 Jagla K, et al., Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes. Mech Dev. 1995 Nov;53(3):345-56
Latest

J:358141 Yin G, et al., Central control of opioid-induced mechanical hypersensitivity and tolerance in mice. Neuron. 2024 Oct 12;