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Pycard MGI Mouse Gene Detail - MGI:1931465 - PYD and CARD domain containing

Summary

  • Symbol

    Pycard

  • Name

    PYD and CARD domain containing

  • Synonyms

    9130417A21Rik, Asc, TMS-1

  • Feature Type

    protein coding gene

  • IDs

    MGI:1931465
    NCBI Gene: 66824

  • Alliance

  • Transcription Start Sites

    3 TSS

Location &
Maps

more

  • Sequence Map

    Chr7:127590545-127593039 bp, - strand

    From NCBI annotation of GRCm39

  • Genome Browsers

  • Genetic Map

    Chromosome 7, 69.88 cM, cytoband F4

  • Mapping Data

    2 experiments

Strain
Comparison

more

  • SNPs within 2kb

    94 from dbSNP Build 142

  • Strain Annotations

    18

Homology

more

  • Human Ortholog

    PYCARD, PYD and CARD domain containing

  • Vertebrate Orthologs

    3

Vertebrate Orthology Source

Alliance of Genome Resources

  • Human Ortholog

    PYCARD, PYD and CARD domain containing

  • Synonyms

    ASC, CARD5, TMS, TMS-1, TMS1

  • Links

  • Chr Location

    16p11.2; chr16:31201486-31203450 (-)  GRCh38

  • MGI Vertebrate Homology

  • HCOP

    vertebrate homology predictions: PYCARD

  • Gene Tree

Mutations,
Alleles, and
Phenotypes

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  • Phenotype Summary

    25 phenotypes from 5 alleles in 10 genetic backgrounds
    10 phenotypes from multigenic genotypes
    421 phenotype references

Phenotype Overview


adipose tissue

behavior/neurological

cardiovascular system

cellular

craniofacial

digestive/alimentary system

embryo

endocrine/exocrine glands

growth/size/body

hearing/vestibular/ear

hematopoietic system

homeostasis/metabolism

integument

immune system

limbs/digits/tail

liver/biliary system

mortality/aging

muscle

nervous system

pigmentation

renal/urinary system

reproductive system

respiratory system

skeleton

taste/olfaction

neoplasm

vision/eye

Click cells to view annotations.

  • All Mutations and Alleles

  • Endonuclease-mediated

  • Gene trapped

  • Targeted

  • Incidental Mutations

  • Find Mice (IMSR)

  • Comparison Matrix

Mice homozygous for disruptions in this gene display abnormalities in interleukin production and secretion as well as increased resistance lethal effects of lipopolysaccharide.

Gene Ontology
(GO)
Classifications

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  • All GO Annotations

  • GO References

Molecular Function


carbohydrate derivative binding

cytoskeletal protein binding

DNA binding

enzyme regulator

hydrolase

ligase

lipid binding

oxidoreductase

RNA binding

signaling receptor activity

signaling receptor binding

transcription

transferase

transporter

Biological Process


carbohydrate derivative metabolism

cell differentiation

cell population proliferation

cellular component organization

DNA-templated transcription

establishment of localization

homeostatic process

immune system process

lipid metabolic process

programmed cell death

protein metabolic process

response to stimulus

signaling

system development

Cellular Component


cell projection

cytoplasmic vesicle

cytoskeleton

cytosol

endoplasmic reticulum

endosome

extracellular region

Golgi apparatus

mitochondrion

membraneless organelle

nucleus

organelle envelope

organelle lumen

plasma membrane

protein-containing complex

synapse

vacuole

Click cells to view annotations.

Expression

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Expression Overview


early conceptus

embryo ectoderm

embryo endoderm

embryo mesoderm

embryo mesenchyme

extraembryonic component

alimentary system

auditory system

branchial arches

cardiovascular system

connective tissue

endocrine system

exocrine system

hemolymphoid system

integumental system

limbs

liver and biliary system

musculoskeletal system

nervous system

olfactory system

reproductive system

respiratory system

urinary system

visual system

Click cells to view annotations.

  • Assay Results

  • Tissues

  • cDNA Data

  • Literature Summary

  • Other Mouse Links

  • Other Vertebrate Links

Sequences &
Gene Models

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  • All Sequences

  • RefSeq

  • UniProt

  • CCDS

  • Ensembl

  • NCBI Gene

Protein
Information

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  • UniProt

    3 Sequences

  • Protein Ontology

    PR:000013514 apoptosis-associated speck-like protein containing a CARD

  • PDB

  • InterPro Domains

    IPR033516 CARD8/ASC/NALP1, CARD domain

    IPR011029 Death-like domain superfamily

  • GlyGen

    Q9EPB4 1 site, 1 N-linked glycan (1 site)

Molecular
Reagents

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  • All nucleic 53

    Primer pair 2

    Microarray probesets 6

References

more

  • Summaries

    Developmental Gene Expression 10

    Gene Ontology 35

    Phenotypes 421

  • Earliest

    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90

  • Latest

    J:361094 Han JH, et al., NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress. Nat Commun. 2024 Feb 26;15(1):1739