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Nedd8 MGI Mouse Gene Detail - MGI:97301 - neural precursor cell expressed, developmentally down-regulated gene 8

Summary

Symbol

Nedd8
Name

neural precursor cell expressed, developmentally down-regulated gene 8
Synonyms

Rub1

Feature Type

protein coding gene
IDs

MGI:97301
NCBI Gene: 18002
Alliance
Transcription Start Sites

7 TSS

Location &
Maps

Sequence Map

Chr14:55899720-55909337 bp, - strand
From NCBI annotation of GRCm39
Genome Browsers

Genetic Map

Chromosome 14, 28.19 cM
Mapping Data

1 experiment

Strain
Comparison

SNPs within 2kb

244 from dbSNP Build 142
Strain Annotations

18

Homology

Human Ortholog

NEDD8, NEDD8 ubiquitin like modifier

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NEDD8, NEDD8 ubiquitin like modifier
Synonyms

NEDD-8
Links
Chr Location

14q12; chr14:24216857-24232367 (-) GRCh38

MGI Vertebrate Homology
HCOP

vertebrate homology predictions: NEDD8
Gene Tree

Mutations,
Alleles, and
Phenotypes

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Phenotype Summary

11 phenotype references

All Mutations and Alleles
Chemically induced (other)
Endonuclease-mediated
Gene trapped
Targeted
Genomic Mutations

1 involving Nedd8
Find Mice (IMSR)

Gene Ontology
(GO)
Classifications

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All GO Annotations
GO References

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

Expression

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Expression Overview

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results
Tissues
cDNA Data
Literature Summary

Other Mouse Links
Other Vertebrate Links

Sequences &
Gene Models

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All Sequences
RefSeq
UniProt
CCDS

Ensembl
NCBI Gene

Protein
Information

less

UniProt

4 Sequences
Protein Ontology
InterPro Domains

IPR050158 Ubiquitin and ubiquitin-like

IPR029071 Ubiquitin-like domain superfamily

Molecular
Reagents

less

All nucleic 146

Genomic 4

Microarray probesets 3

References

Summaries

Developmental Gene Expression 12

Gene Ontology 9

Phenotypes 11
Earliest

J:1344 Kumar S, et al., Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun. 1992 Jun 30;185(3):1155-61
Latest

J:346004 Jiang Y, et al., Targeting NEDD8 suppresses surgical stress-facilitated metastasis of colon cancer via restraining regulatory T cells. Cell Death Dis. 2024 Jan 5;15(1):8