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Sry MGI Mouse Gene Detail - MGI:98660 - sex determining region of Chr Y

Summary

  • Symbol

    Sry

  • Name

    sex determining region of Chr Y

  • Synonyms

    Tdf, Tdy

  • Feature Type

    protein coding gene

  • IDs

    MGI:98660
    NCBI Gene: 21674

  • Alliance

Location &
Maps

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  • Sequence Map

    ChrY:2662471-2663658 bp, - strand

    From NCBI annotation of GRCm39

  • Genome Browsers

  • Genetic Map

    Chromosome Y, cytoband p

  • Mapping Data

    10 experiments

Strain
Comparison

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  • Strain Annotations

    1

  • PCR

  • RFLP

Homology

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  • Human Ortholog

    SRY, sex determining region Y

  • Vertebrate Orthologs

    3

Vertebrate Orthology Source

Alliance of Genome Resources

  • Human Ortholog

    SRY, sex determining region Y

  • Synonyms

    SRXX1, SRXY1, TDF, TDY

  • Links

  • Chr Location

    Yp11.2; chrY:2786855-2787682 (-)  GRCh38

  • MGI Vertebrate Homology

  • HCOP

    vertebrate homology predictions: SRY

  • Gene Tree

Human Diseases

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  • Diseases

    3 with human SRY associations

Mutations,
Alleles, and
Phenotypes

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  • Phenotype Summary

    15 phenotypes from 11 alleles in 10 genetic backgrounds
    14 phenotypes from multigenic genotypes
    1 images
    117 phenotype references

Phenotype Overview


adipose tissue

behavior/neurological

cardiovascular system

cellular

craniofacial

digestive/alimentary system

embryo

endocrine/exocrine glands

growth/size/body

hearing/vestibular/ear

hematopoietic system

homeostasis/metabolism

integument

immune system

limbs/digits/tail

liver/biliary system

mortality/aging

muscle

nervous system

pigmentation

renal/urinary system

reproductive system

respiratory system

skeleton

taste/olfaction

neoplasm

vision/eye

Click cells to view annotations.

  • All Mutations and Alleles

  • Endonuclease-mediated

  • Spontaneous

  • Targeted

  • Transgenic

  • Genomic Mutations

    2 involving Sry

  • Incidental Mutations

  • Find Mice (IMSR)

  • Comparison Matrix

  • Recombinase Activity

Variations in expression of alleles on specific backgrounds result in partial and/or complete male to female sex reversal. Deletion of alleles results in XY females.

Gene Ontology
(GO)
Classifications

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  • All GO Annotations

  • GO References

Molecular Function


carbohydrate derivative binding

cytoskeletal protein binding

DNA binding

enzyme regulator

hydrolase

ligase

lipid binding

oxidoreductase

RNA binding

signaling receptor activity

signaling receptor binding

transcription

transferase

transporter

Biological Process


carbohydrate derivative metabolism

cell differentiation

cell population proliferation

cellular component organization

DNA-templated transcription

establishment of localization

homeostatic process

immune system process

lipid metabolic process

programmed cell death

protein metabolic process

response to stimulus

signaling

system development

Cellular Component


cell projection

cytoplasmic vesicle

cytoskeleton

cytosol

endoplasmic reticulum

endosome

extracellular region

Golgi apparatus

mitochondrion

membraneless organelle

nucleus

organelle envelope

organelle lumen

plasma membrane

protein-containing complex

synapse

vacuole

Click cells to view annotations.

Expression

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Expression Overview


early conceptus

embryo ectoderm

embryo endoderm

embryo mesoderm

embryo mesenchyme

extraembryonic component

alimentary system

auditory system

branchial arches

cardiovascular system

connective tissue

endocrine system

exocrine system

hemolymphoid system

integumental system

limbs

liver and biliary system

musculoskeletal system

nervous system

olfactory system

reproductive system

respiratory system

urinary system

visual system

Click cells to view annotations.

  • Assay Results

  • Tissues

  • cDNA Data

  • Literature Summary

  • Other Mouse Links

Sequences &
Gene Models

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  • All Sequences

  • RefSeq

  • UniProt

  • CCDS

  • Ensembl

  • NCBI Gene

Protein
Information

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  • UniProt

    3 Sequences

  • InterPro Domains

    IPR009071 High mobility group box domain

    IPR036910 High mobility group box domain superfamily

    IPR050140 SRY-related HMG-box transcription factors

Molecular
Reagents

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  • All nucleic 104

    Genomic 44

    Primer pair 37

    Other 3

    Microarray probesets 5

Other
Accession IDs

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MGD-MRK-14604, MGD-MRK-14983, MGD-MRK-14986

References

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  • Summaries

    Developmental Gene Expression 115

    Gene Ontology 23

    Phenotypes 117

  • Earliest

    J:6802 Eicher EM, et al., Mus poschiavinus Y chromosome in the C57BL/6J murine genome causes sex reversal. Science. 1982 Aug 6;217(4559):535-7

  • Latest

    J:360566 Amato-Menker CJ, et al., XX sex chromosome complement modulates immune responses to heat-killed Streptococcus pneumoniae immunization in a microbiome-dependent manner. Biol Sex Differ. 2024 Mar 14;15(1):21