Leptin is associated with an increased female colorectal cancer risk: a nested case-control study in Japan - PubMed
Comparative Study
doi: 10.1159/000086988. Epub 2005 Jul 14.
Hideaki Toyoshima, Kenji Wakai, Masayo Kojima, Koji Suzuki, Yoshiyuki Watanabe, Norihiko Hayakawa, Hiroshi Yatsuya, Takaaki Kondo, Shinkan Tokudome, Shuji Hashimoto, Sadao Suzuki, Miyuki Kawado, Kotaro Ozasa, Yoshinori Ito, Akiko Tamakoshi
Affiliations
- PMID: 16020976
- DOI: 10.1159/000086988
Comparative Study
Leptin is associated with an increased female colorectal cancer risk: a nested case-control study in Japan
Koji Tamakoshi et al. Oncology. 2005.
Abstract
Objective: To elucidate whether leptin is involved in the etiology of female colorectal cancer.
Methods: A case-control study nested in the Japan Collaborative Cohort Study. We compared serum leptin levels in 58 cases of female colorectal cancer with those in 145 controls matched for study area and age. Data were analyzed using a conditional logistic regression model with adjustments for known risk factors for the development of colorectal cancer. Quintile cutoff points were determined on the distribution of leptin levels in cases and controls combined.
Results: Serum geometric mean levels of leptin were 6.88 ng/ml in cases and 6.00 ng/ml in controls. The odds ratios of female colorectal cancer risk were 1.40 (95% confidence interval, CI: 0.41-4.78) for the category of the second and third quintiles combined, and 4.84 (CI: 1.29-18.1) for the category of the fourth and fifth quintiles combined relative to the first quintile after adjustment for body mass index (BMI), life-style factors, reproductive factors, and hormonal variables including insulin-like growth factor and its binding protein.
Conclusion: Our results suggest that leptin most likely increases the risk of female colorectal cancer substantially independent of BMI.
(c) 2005 S. Karger AG, Basel.
Similar articles
-
Insulin-like growth factor II and colorectal cancer risk in women.
Hunt KJ, Toniolo P, Akhmedkhanov A, Lukanova A, Dechaud H, Rinaldi S, Zeleniuch-Jacquotte A, Shore RE, Riboli E, Kaaks R. Hunt KJ, et al. Cancer Epidemiol Biomarkers Prev. 2002 Sep;11(9):901-5. Cancer Epidemiol Biomarkers Prev. 2002. PMID: 12223436
-
Jiang B, Liu DB, Zhang X, DU LL, Han CZ. Jiang B, et al. Zhonghua Wei Chang Wai Ke Za Zhi. 2009 May;12(3):264-8. Zhonghua Wei Chang Wai Ke Za Zhi. 2009. PMID: 19434535 Chinese.
-
Otani T, Iwasaki M, Sasazuki S, Inoue M, Tsugane S; Japan Public Health Center-Based Prospective Study Group. Otani T, et al. Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):690-5. doi: 10.1158/1055-9965.EPI-05-0708. Cancer Epidemiol Biomarkers Prev. 2006. PMID: 16614110
-
Suzuki S, Kojima M, Tokudome S, Suzuki K, Ozasa K, Ito Y, Inaba Y, Tajima K, Nakachi K, Watanabe Y, Tamakoshi A; JACC Study Group. Suzuki S, et al. Asian Pac J Cancer Prev. 2009 Dec;10 Suppl:45-9. Asian Pac J Cancer Prev. 2009. PMID: 20553081
-
[Epidemiology of colorectal cancer].
Yoshihara M, Hiyama T, Tanaka S. Yoshihara M, et al. Nihon Naika Gakkai Zasshi. 2007 Feb 10;96(2):200-6. doi: 10.2169/naika.96.200. Nihon Naika Gakkai Zasshi. 2007. PMID: 17370582 Review. Japanese. No abstract available.
Cited by
-
Bobe G, Murphy G, Rogers CJ, Hance KW, Albert PS, Laiyemo AO, Sansbury LB, Lanza E, Schatzkin A, Cross AJ. Bobe G, et al. Cancer Epidemiol Biomarkers Prev. 2010 Jun;19(6):1441-52. doi: 10.1158/1055-9965.EPI-09-1082. Epub 2010 May 25. Cancer Epidemiol Biomarkers Prev. 2010. PMID: 20501764 Free PMC article.
-
Leptin gene variants and colorectal cancer risk: Sex-specific associations.
Chun KA, Kocarnik JM, Hardikar SS, Robinson JR, Berndt SI, Chan AT, Figueiredo JC, Lindor NM, Song M, Schoen RE, Hayes RB, Potter JD, Nassir R, Bézieau S, Le Marchand L, Slattery ML, White E, Peters U, Newcomb PA. Chun KA, et al. PLoS One. 2018 Oct 31;13(10):e0206519. doi: 10.1371/journal.pone.0206519. eCollection 2018. PLoS One. 2018. PMID: 30379922 Free PMC article.
-
Rezaei-Tavirani M, Safaei A, Zali MR. Rezaei-Tavirani M, et al. Iran J Cancer Prev. 2013 Fall;6(4):179-85. Iran J Cancer Prev. 2013. PMID: 25250132 Free PMC article. Review.
-
Piringer G, Fridrik M, Fridrik A, Leiherer A, Zabernigg A, Greil R, Eisterer W, Tschmelitsch J, Lang A, Frantal S, Burgstaller S, Gnant M, Thaler J; Austrian Breast and Colorectal Cancer Study Group (ABCSG). Piringer G, et al. Support Care Cancer. 2018 Apr;26(4):1345-1352. doi: 10.1007/s00520-017-3961-8. Epub 2017 Nov 22. Support Care Cancer. 2018. PMID: 29168033 Clinical Trial.
-
Molecular mechanisms of cancer development in obesity.
Khandekar MJ, Cohen P, Spiegelman BM. Khandekar MJ, et al. Nat Rev Cancer. 2011 Nov 24;11(12):886-95. doi: 10.1038/nrc3174. Nat Rev Cancer. 2011. PMID: 22113164 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical