Reduced glycaemic and insulinaemic responses following isomaltulose ingestion: implications for postprandial substrate use - PubMed
Randomized Controlled Trial
. 2009 Nov;102(10):1408-13.
doi: 10.1017/S0007114509990687. Epub 2009 Aug 11.
Affiliations
- PMID: 19671200
- DOI: 10.1017/S0007114509990687
Randomized Controlled Trial
Reduced glycaemic and insulinaemic responses following isomaltulose ingestion: implications for postprandial substrate use
Judith G P van Can et al. Br J Nutr. 2009 Nov.
Abstract
The impact of slow digestible sources of dietary carbohydrate in reducing the risk of developing obesity and related metabolic disorders is unclear. The aim of the present study was to compare the postprandial metabolic response to the ingestion of sucrose v. isomaltulose. We hypothesised that the reduced digestion and absorption rate of isomaltulose would result in lower glycaemic and insulinaemic responses when compared with the ingestion of sucrose, leading to greater postprandial fat oxidation rates. In a randomised, single-blind, cross-over study, ten overweight subjects ingested two different carbohydrate drinks (sucrose and isomaltulose, 75 g carbohydrate equivalents) following an overnight fast (08.40 hours) and with a standardised meal (12.30 hours, 25 % of total energy content was provided as either a sucrose or isomaltulose drink). Blood samples were taken before ingestion and every 30 min thereafter for a period of 3 h, substrate use was assessed by indirect calorimetry and breath samples were collected. Ingestion of carbohydrates with a mixed meal resulted in a lower peak glucose and insulin response and a lower change in area under the curve (DeltaAUC) following isomaltulose when compared with sucrose. Together with the lower glucose and insulin responses, postprandial fat oxidation rates were higher (14 %) with isomaltulose when compared with sucrose when ingested with a mixed meal (P = 0.02). The attenuated rise in glucose and insulin concentrations following isomaltulose results in reduced inhibition of postprandial fat oxidation. The metabolic response to isomaltulose co-ingestion suggests that this may represent an effective nutritional strategy to counteract overweight-induced metabolic disturbances.
Similar articles
-
van Can JG, Ijzerman TH, van Loon LJ, Brouns F, Blaak EE. van Can JG, et al. Br J Nutr. 2009 Nov;102(10):1395-9. doi: 10.1017/S000711450999050X. Epub 2009 Aug 7. Br J Nutr. 2009. PMID: 19664296 Clinical Trial.
-
van Can JG, van Loon LJ, Brouns F, Blaak EE. van Can JG, et al. Br J Nutr. 2012 Oct;108(7):1210-7. doi: 10.1017/S0007114511006714. Epub 2011 Dec 15. Br J Nutr. 2012. PMID: 22172468 Clinical Trial.
-
König D, Theis S, Kozianowski G, Berg A. König D, et al. Nutrition. 2012 Jun;28(6):651-6. doi: 10.1016/j.nut.2011.09.019. Epub 2012 Jan 21. Nutrition. 2012. PMID: 22264450 Clinical Trial.
-
Isomaltulose (Palatinose): a review of biological and toxicological studies.
Lina BA, Jonker D, Kozianowski G. Lina BA, et al. Food Chem Toxicol. 2002 Oct;40(10):1375-81. doi: 10.1016/s0278-6915(02)00105-9. Food Chem Toxicol. 2002. PMID: 12387299 Review.
-
Current studies on sucrose isomerase and biological isomaltulose production using sucrose isomerase.
Mu W, Li W, Wang X, Zhang T, Jiang B. Mu W, et al. Appl Microbiol Biotechnol. 2014 Aug;98(15):6569-82. doi: 10.1007/s00253-014-5816-2. Epub 2014 May 28. Appl Microbiol Biotechnol. 2014. PMID: 24866943 Review.
Cited by
-
Amano T, Katayama S, Okamoto Y, Otsuka J, Fujii N, Kenny GP, Nishiyasu T, Enoki Y, Maejima D. Amano T, et al. Eur J Nutr. 2021 Dec;60(8):4519-4529. doi: 10.1007/s00394-021-02614-z. Epub 2021 Jun 15. Eur J Nutr. 2021. PMID: 34129073 Clinical Trial.
-
Incretin Hormones: The Link between Glycemic Index and Cardiometabolic Diseases.
Salvatore T, Nevola R, Pafundi PC, Monaco L, Ricozzi C, Imbriani S, Rinaldi L, Sasso FC. Salvatore T, et al. Nutrients. 2019 Aug 13;11(8):1878. doi: 10.3390/nu11081878. Nutrients. 2019. PMID: 31412576 Free PMC article. Review.
-
Impact of postprandial glycaemia on health and prevention of disease.
Blaak EE, Antoine JM, Benton D, Björck I, Bozzetto L, Brouns F, Diamant M, Dye L, Hulshof T, Holst JJ, Lamport DJ, Laville M, Lawton CL, Meheust A, Nilson A, Normand S, Rivellese AA, Theis S, Torekov SS, Vinoy S. Blaak EE, et al. Obes Rev. 2012 Oct;13(10):923-84. doi: 10.1111/j.1467-789X.2012.01011.x. Epub 2012 Jul 11. Obes Rev. 2012. PMID: 22780564 Free PMC article. Review.
-
Nutritional strategies to attenuate postprandial glycemic response.
Pasmans K, Meex RCR, van Loon LJC, Blaak EE. Pasmans K, et al. Obes Rev. 2022 Sep;23(9):e13486. doi: 10.1111/obr.13486. Epub 2022 Jun 10. Obes Rev. 2022. PMID: 35686720 Free PMC article. Review.
-
Xie J, Li J, Qin Q, Ning H, Long Z, Gao Y, Yu Y, Han Z, Wang F, Wang M. Xie J, et al. Adv Nutr. 2022 Oct 2;13(5):1901-1913. doi: 10.1093/advances/nmac057. Adv Nutr. 2022. PMID: 35595510 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical