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Effect of prenatal exposure to fine particulate matter on ventilatory lung function of preschool children of non-smoking mothers - PubMed

Effect of prenatal exposure to fine particulate matter on ventilatory lung function of preschool children of non-smoking mothers

Wieslaw A Jedrychowski et al. Paediatr Perinat Epidemiol. 2010 Sep.

Abstract

Impaired fetal development is associated with a number of adult chronic diseases and it is believed that these associations arise as a result of the phenomenon of prenatal programming, which involves persisting changes in structure and function of various body organs caused by ambient factors during critical and vulnerable periods of early development. The main goal of the study was to assess the association between lung function in early childhood and prenatal exposure to fine particulate matter (PM(2.5)), which represents a wide range of chemical compounds potentially hazardous for fetal development. Among pregnant women recruited prenatally to the study, personal measurements of PM(2.5) were performed over 48 h in the second trimester of pregnancy. After delivery, infants were followed for 5 years; the interviewers visited participants in their homes to record children's respiratory symptoms every 3 months in the child's first 2 years of life and every 6 months thereafter. In the fifth year of the follow-up, children were invited for standard lung function testing of levels of forced vital capacity (FVC), forced expiratory volume in 1 s (FEV(1)) and forced expiratory volume in 0.5 s (FEV(0.5)). There were 176 children of non-smoking mothers, who performed at least two acceptable spirometry measurements. Multivariable linear regression showed a significant deficit of FVC at the highest quartile of PM(2.5) exposure (beta coefficient = -91.9, P = 0.008), after adjustment for covariates (age, gender, birthweight, height and wheezing). Also FEV(1) level in children was inversely correlated with prenatal exposure to PM(2.5), and the average FEV(1) deficit amounted to 87.7 mL (P = 0.008) at the higher level of exposure. Although the effect of PM(2.5) exposure on FEV(0.5) was proportionally weaker (-72.7, P = 0.026), it was also statistically significant. The lung function level was inversely and significantly associated with the wheezing recorded over the follow-up. The findings showed that significant lung function deficits in early childhood are associated with prenatal exposure to fine particulate matter, which may affect fetal lung growth.

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Figures

Figure 1
Figure 1

Sampling instruments placed in the backpack

Figure 2
Figure 2

One of the study participants wearing the backpack with personal monitoring sampler for collection of fine particulate matter

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References

    1. Xu X, Ding H, Wang X. Acute effects of total suspended particles and sulfur dioxides on preterm delivery: a community-based cohort study. Archives of Environmental Health. 1995;50:407–415. - PubMed
    1. Wang X, Ding H, Ryan L, Xu X. Association between air pollution and low birth weight: a community-based study. Environmental Health Perspectives. 1997;105:514–520. - PMC - PubMed
    1. Perera F, Whyatt R, Jedrychowski W, Rauh V, Manchester D, Santella RM, et al. Recent developments in molecular epidemiology: A study of the effects of environmental polycyclic aromatic hydrocarbons on birth outcomes in Poland. American Journal of Epidemiology. 1998;147:309–314. - PubMed
    1. Loomis D, Castillejos M, Gold DR, McDonnell W, Borja-Aburto VH. Air pollution and infant mortality in Mexico City. Epidemiology. 1999;10:118–123. - PubMed
    1. Ritz B, Yu F, Chapa G, Fruin S. Effect of air pollution on preterm birth among children born in Southern California between 1989 and 1993. Epidemiology. 2000;11:502–511. - PubMed

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