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Major depression during and after the menopausal transition: Study of Women's Health Across the Nation (SWAN) - PubMed

Major depression during and after the menopausal transition: Study of Women's Health Across the Nation (SWAN)

J T Bromberger et al. Psychol Med. 2011 Sep.

Erratum in

  • Psychol Med.2011 Oct;41(10):2238

Abstract

Background: It is unclear whether risk for major depression during the menopausal transition or immediately thereafter is increased relative to pre-menopause. We aimed to examine whether the odds of experiencing major depression were greater when women were peri- or post-menopausal compared to when they were pre-menopausal, independent of a history of major depression at study entry and annual measures of vasomotor symptoms (VMS), serum levels of, or changes in, estradiol (E2), follicular stimulating hormone (FSH) or testosterone (T) and relevant confounders.

Method: Participants included the 221 African American and Caucasian women, aged 42-52 years, who were pre-menopausal at entry into the Pittsburgh site of a community-based study of menopause, the Study of Women's Health Across the Nation (SWAN). We conducted the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID) to assess diagnoses of lifetime, annual and current major depression at baseline and at annual follow-ups. Psychosocial and health factors, and blood samples for assay of reproductive hormones, were obtained annually.

Results: Women were two to four times more likely to experience a major depressive episode (MDE) when they were peri-menopausal or early post-menopausal. Repeated-measures logistic regression analyses showed that the effect of menopausal status was independent of history of major depression and annually measured upsetting life events, psychotropic medication use, VMS and serum levels of or changes in reproductive hormones. History of major depression was a strong predictor of major depression throughout the study.

Conclusions: The risk of major depression is greater for women during and immediately after the menopausal transition than when they are pre-menopausal.

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Conflict of interest statement

All authors report no conflict of interest.

Figures

Figure 1
Figure 1

Number of Person-Years of Observations (visits) for Total Sample (maximum possible=1913), and for Premenopause, Perimenopause, and Postmenopause Visits.

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References

    1. Avis NE, Brambilla D, McKinlay SM, Vass K. A longitudinal analysis of the association between menopause and depression. Results from the Massachusetts Women’s Health Study. Annals of Epidemiology. 1994;4:214–220. - PubMed
    1. Bromberger JT, Matthews KA, Schott LL, Brockwell S, Avis N, Kravitz HM, Everson-Rose SA, Gold EB, Sowers M, Randolph J., Jr Depressive symptoms during the menopausal transition: the Study of Women’s Health Across the Nation (SWAN) Journal of Affective Disorder. 2007;103:267–272. - PMC - PubMed
    1. Burger HG, Dudley EC, Hopper JL, Groome N, Guthrie JR, Green A, Dennerstein L. Prospectively easured levels of Serum Follicle-stimulating hormone, estradiol, and the dimeric inhibins during the menopausal transition in a population-based cohrt of women*. Journal of Clinical Endocrinology & Metabolism. 1999;84:4025–4030. - PubMed
    1. Cohen LS, Soares CN, Vitonis AF, otto MW, Harlow BL. Risk for new onset of depression during the menopausal transition: The Harvard study of moods and cycles. Archives of General Psychiatry. 2006;63:385–390. - PubMed
    1. Freeman EW, Sammel MD, Lui L, Gracia CR, Nelson DB, Hollander L. Hormones and menopausal status as predictors of depression in women in transition to menopause. Archives of General Psychiatry. 2004;61:62–70. - PubMed

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