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RNA interference in fungi: pathways, functions, and applications - PubMed

Review

. 2011 Sep;10(9):1148-55.

doi: 10.1128/EC.05109-11. Epub 2011 Jul 1.

Affiliations

PMID: 21724934
PMCID: PMC3187057
DOI: 10.1128/EC.05109-11

Review

RNA interference in fungi: pathways, functions, and applications

Yunkun Dang et al. Eukaryot Cell. 2011 Sep.

Abstract

Small RNA molecules of about 20 to 30 nucleotides function in gene regulation and genomic defense via conserved eukaryotic RNA interference (RNAi)-related pathways. The RNAi machinery consists of three core components: Dicer, Argonaute, and RNA-dependent RNA polymerase. In fungi, the RNAi-related pathways have three major functions: genomic defense, heterochromatin formation, and gene regulation. Studies of Schizosaccharomyces pombe and Neurospora, and other fungi have uncovered surprisingly diverse small RNA biogenesis pathways, suggesting that fungi utilize RNAi-related pathways in various cellular processes to adapt to different environmental conditions. These studies also provided important insights into how RNAi functions in eukaryotic systems in general. In this review, we will discuss our current understanding of the fungal RNAi-related pathways and their functions, with a focus on filamentous fungi. We will also discuss how RNAi can be used as a tool in fungal research.

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Figures

**Fig. 1.**
sRNA biogenesis pathways and RNAi functions in Neurospora. See text for details.

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RNA interference in fungi: pathways, functions, and applications - PubMed

RNA interference in fungi: pathways, functions, and applications

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