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Health effects of naturally radioactive water ingestion: the need for enhanced studies - PubMed

Review

. 2011 Dec;119(12):1676-80.

doi: 10.1289/ehp.1003224. Epub 2011 Aug 2.

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Review

Health effects of naturally radioactive water ingestion: the need for enhanced studies

Irina Guseva Canu et al. Environ Health Perspect. 2011 Dec.

Abstract

Background: Radiological pollution is a potentially important aspect of water quality. However, relatively few studies have been conducted to document its possible health effects.

Objective: In this commentary we discuss available epidemiological findings and related data from experimental studies concerning the health effects of naturally radioactive water ingestion.

Discussion: Despite modest epidemiological evidence of uranium nephrotoxicity and radium effects on bone, available data are not sufficient to quantify the health effects of naturally occurring radionuclides in water. Methodological limitations (exposure measurement methods, control for confounding, sample size) affect most studies. Power calculations should be conducted before launching new epidemiological studies focusing on late pathological outcomes. Studies based on biomarkers of exposure and adverse effects may be helpful but should involve more specific molecules than biomarkers used in previous studies. Experimental data on ingestion of drinking water are limited to uranium studies, and there is some disagreement between these studies about the nephrotoxicity threshold.

Conclusion: Further experimental and enhanced epidemiological studies should help to reduce uncertainties resulting from dose estimation to dose-response characterization.

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Conflict of interest statement

The authors declare they have no actual or potential competing financial interests.

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References

    1. Adler S. Novel kidney injury biomarkers. J Ren Nutr. 2010;20(suppl 5):S15–S18. - PubMed
    1. ATSDR (Agency for Toxic Substances and Disease Registry) Atlanta, GA: Agency for Toxic Substances and Disease Registry; 1990. Toxicological Profile for Radium. - PubMed
    1. Auvinen A, Kurttio P, Pekkanen J, Pukkala E, Ilus T, Salonen L. Uranium and other natural radionuclides in drinking water and risk of leukemia: a case–cohort study in Finland. Cancer Causes Control. 2002;13(9):825–829. - PubMed
    1. Auvinen A, Salonen L, Pekkanen J, Pukkala E, Ilus T, Kurttio P. Radon and other natural radionuclides in drinking water and risk of stomach cancer: a case–cohort study in Finland. Int J Cancer. 2005;114(1):109–113. - PubMed
    1. Bean JA, Isacson P, Hausler WJ, Jr, Kohler J. Drinking water and cancer incidence in Iowa. I. Trends and incidence by source of drinking water and size of municipality. Am J Epidemiol. 1982;116(6):912–923. - PubMed

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