Virgin coconut oil maintains redox status and improves glycemic conditions in high fructose fed rats - PubMed
Virgin coconut oil maintains redox status and improves glycemic conditions in high fructose fed rats
Arunaksharan Narayanankutty et al. J Food Sci Technol. 2016 Jan.
Abstract
Virgin Coconut Oil (VCO), extracted from fresh coconut kernel possess similar fatty acid composition to that of Copra Oil (CO), a product of dried kernel. Although CO forms the predominant dietary constituent in south India, VCO is being promoted for healthy life due to its constituent antioxidant molecules. High fructose containing CO is an established model for insulin resistance and steatohepatitis in rodents. In this study, replacement of CO with VCO in high fructose diet markedly improved the glucose metabolism and dyslipidemia. The animals fed VCO diet had only 17 % increase in blood glucose level compared to CO fed animals (46 %). Increased level of GSH and antioxidant enzyme activities in VCO fed rats indicate improved hepatic redox status. Reduced lipid peroxidation and carbonyl adducts in VCO fed rats well corroborate with the histopathological findings that hepatic damage and steatosis were comparatively reduced than the CO fed animals. These results suggest that VCO could be an efficient nutraceutical in preventing the development of diet induced insulin resistance and associated complications possibly through its antioxidant efficacy.
Keywords: Copra oil; Hepatosteatosis; High fructose diet; Insulin resistance; Oxidative stress; Virgin coconut oil.
Figures

i Variation in the glucose tolerance of animals under the dietary medications: the animals were given 5 g/kg glucose orally and the blood glucose levels were checked at 30, 60, 90 and 120 mins, respectively. ii Antioxidant enzyme activities such as GSH, GST, SOD, GR, GPx and Catalase in the liver tissue of reference diet, CO and VCO containing diet fed groups of animals. iii Hematoxylin-Eosin stained sections of liver tissues of male Wistar rats; reference diet fed animals (a), CO containing diet fed animals (b) and VCO containing diet fed animals (c) are shown in the Figure. CO fed groups showed signs of hepatic steatosis, observed as vesicles (black arrows)
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