Linear antimicrobial peptides with activity against herpes simplex virus 1 and Aichi virus - PubMed

Linear antimicrobial peptides with activity against herpes simplex virus 1 and Aichi virus

Liana Costa Pereira Vilas Boas et al. Biopolymers. 2017 Mar.

Abstract

Viruses are the major cause of disease and mortality worldwide. Nowadays there are treatments based on antivirals or prophylaxis with vaccines. However, the rising number of reports of viral resistance to current antivirals and the emergence of new types of virus has concerned the scientific community. In this scenario, the search for alternative treatments has led scientists to the discovery of antimicrobial peptides (AMPs) derived from many different sources. Since some of them have shown antiviral activities, here we challenged 10 synthetic peptides from different animal and plant sources against, herpes simplex virus 1 (HSV-1), and Aichi virus. Among them, the highlight was Pa-MAP from the polar fish Pleuronectes americanus, which caused around 90% of inhibition of the HSV with a selectivity index of 5 and a virucidal mechanism of action. Moreover, LL-37 from human neutrophils showed 96% of inhibition against the Aichi virus, showing a selectivity index of 3.4. The other evaluated peptides did not show significant antiviral activity. In conclusion, the present study demonstrated that Pa-MAP seems to be a reliable candidate for a possible alternative drug to treat HSV-1 infections. © 2016 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 108: 1-6, 2017.

Keywords: Aichi virus; HSV-1; antiviral peptides; virucidal.

Similar articles

• Antiviral effects of synthetic membrane-active peptides on herpes simplex virus, type 1.

  Egal M, Conrad M, MacDonald DL, Maloy WL, Motley M, Genco CA. Egal M, et al. Int J Antimicrob Agents. 1999 Sep;13(1):57-60. doi: 10.1016/s0924-8579(99)00094-1. Int J Antimicrob Agents. 1999. PMID: 10563406

• A wide range of medium-sized, highly cationic, alpha-helical peptides show antiviral activity against herpes simplex virus.

  Jenssen H, Andersen JH, Mantzilas D, Gutteberg TJ. Jenssen H, et al. Antiviral Res. 2004 Nov;64(2):119-26. doi: 10.1016/j.antiviral.2004.08.003. Antiviral Res. 2004. PMID: 15498607

• Antiviral activity of sandalwood oil against herpes simplex viruses-1 and -2.

  Benencia F, Courrèges MC. Benencia F, et al. Phytomedicine. 1999 May;6(2):119-23. doi: 10.1016/S0944-7113(99)80046-4. Phytomedicine. 1999. PMID: 10374251

• Antiviral and virucidal activities of natural products.

  Arakawa T, Yamasaki H, Ikeda K, Ejima D, Naito T, Koyama AH. Arakawa T, et al. Curr Med Chem. 2009;16(20):2485-97. doi: 10.2174/092986709788682065. Curr Med Chem. 2009. PMID: 19601794 Review.

• Antiviral peptides as promising therapeutic drugs.

  Vilas Boas LCP, Campos ML, Berlanda RLA, de Carvalho Neves N, Franco OL. Vilas Boas LCP, et al. Cell Mol Life Sci. 2019 Sep;76(18):3525-3542. doi: 10.1007/s00018-019-03138-w. Epub 2019 May 17. Cell Mol Life Sci. 2019. PMID: 31101936 Free PMC article. Review.

Cited by

• In-Depth In Silico Search for Cuttlefish (Sepia officinalis) Antimicrobial Peptides Following Bacterial Challenge of Haemocytes.

  Benoist L, Houyvet B, Henry J, Corre E, Zanuttini B, Zatylny-Gaudin C. Benoist L, et al. Mar Drugs. 2020 Aug 24;18(9):439. doi: 10.3390/md18090439. Mar Drugs. 2020. PMID: 32847054 Free PMC article.

• Antiviral and Immunomodulatory Properties of Antimicrobial Peptides Produced by Human Keratinocytes.

  Chessa C, Bodet C, Jousselin C, Wehbe M, Lévêque N, Garcia M. Chessa C, et al. Front Microbiol. 2020 Jun 3;11:1155. doi: 10.3389/fmicb.2020.01155. eCollection 2020. Front Microbiol. 2020. PMID: 32582097 Free PMC article. Review.

• A Systematic Review of Second-Line Treatments in Antiviral Resistant Strains of HSV-1, HSV-2, and VZV.

  Lince KC, DeMario VK, Yang GT, Tran RT, Nguyen DT, Sanderson JN, Pittman R, Sanchez RL. Lince KC, et al. Cureus. 2023 Mar 9;15(3):e35958. doi: 10.7759/cureus.35958. eCollection 2023 Mar. Cureus. 2023. PMID: 37041924 Free PMC article. Review.

• The Peptide A-3302-B Isolated from a Marine Bacterium Micromonospora sp. Inhibits HSV-2 Infection by Preventing the Viral Egress from Host Cells.

  Sureram S, Arduino I, Ueoka R, Rittà M, Francese R, Srivibool R, Darshana D, Piel J, Ruchirawat S, Muratori L, Lembo D, Kittakoop P, Donalisio M. Sureram S, et al. Int J Mol Sci. 2022 Jan 15;23(2):947. doi: 10.3390/ijms23020947. Int J Mol Sci. 2022. PMID: 35055133 Free PMC article.

• LL-37 disrupts the Kaposi's sarcoma-associated herpesvirus envelope and inhibits infection in oral epithelial cells.

  Brice DC, Toth Z, Diamond G. Brice DC, et al. Antiviral Res. 2018 Oct;158:25-33. doi: 10.1016/j.antiviral.2018.07.025. Epub 2018 Aug 2. Antiviral Res. 2018. PMID: 30076864 Free PMC article.

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Wiley

• Other Literature Sources

  • scite Smart Citations