Short- and Long-Term Changes in Health-Related Quality of Life with Weight Loss: Results from a Randomized Controlled Trial - PubMed
Randomized Controlled Trial
. 2018 Jun;26(6):985-991.
doi: 10.1002/oby.22187. Epub 2018 Apr 20.
Thomas A Wadden 1 , Jena Shaw Tronieri 1 , Robert I Berkowitz 1 3 , Ariana M Chao 1 4 , Naji Alamuddin 1 5 , Sharon M Leonard 1 , Raymond Carvajal 1 , Zayna M Bakizada 1 , Emilie Pinkasavage 1 , Kathryn A Gruber 1 , Olivia A Walsh 1 , Nasreen Alfaris 6
Affiliations
- PMID: 29676530
- PMCID: PMC5970047
- DOI: 10.1002/oby.22187
Randomized Controlled Trial
Short- and Long-Term Changes in Health-Related Quality of Life with Weight Loss: Results from a Randomized Controlled Trial
Rebecca L Pearl et al. Obesity (Silver Spring). 2018 Jun.
Abstract
Objective: The objective of this study was to determine the effects of weight loss and weight loss maintenance (WLM) on weight-specific health-related quality of life in a 66-week trial.
Methods: Adults with obesity (N = 137, 86.1% female, 68.6% black, mean age = 46.1 years) who had lost ≥ 5% of initial weight in a 14-week intensive lifestyle intervention/low-calorie diet (LCD) program were randomly assigned to lorcaserin or placebo for an additional 52-week WLM program. The Impact of Weight on Quality of Life-Lite (IWQOL-Lite) scale (including five subscales), Patient Health Questionnaire-9 (depression), and Perceived Stress Scale were administered at the start of the 14-week LCD program, randomization, and week 52 of the randomized controlled trial (i.e., 66 weeks total).
Results: Significant improvements in all outcomes, except weight-related public distress, were found following the 14-week LCD program (P values < 0.05). Improvements were largely maintained during the 52-week randomized controlled trial, despite weight regain of 2.0 to 2.5 kg across treatment groups. Participants who lost ≥ 10% of initial weight achieved greater improvements in physical function, self-esteem, sexual life, and the IWQOL-Lite total score than those who lost < 5% and did not differ from those who lost 5% to 9.9%.
Conclusions: Improvements in weight-specific health-related quality of life were achieved with moderate weight loss and were sustained during WLM.
Trial registration: ClinicalTrials.gov NCT02388568.
© 2018 The Obesity Society.
Figures

Changes in IWQOL – Lite scores by percent weight loss Note. Analyses of covariance showed significant differences for the IWQOL-Lite total score, as well as the physical function, self-esteem, and sexual life subscales, controlling for all covariates (p values < 0.04; p values > 0.05 for work and public distress subscales). Change scores were significantly smaller for participants who lost < 5% of their weight (n = 32) in comparison to those who lost ≥ 10% (n = 34). IWQOL-Lite total change scores were significantly greater for patients who lost 5–9.9% (n = 23) than for those who lost <5% of their weight (p = 0.04). Scores did not differ between participants who lost ≥ 5% vs. ≥ 10% of their starting weight. IWQOL = Impact of Weight on Quality of Life.
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