Positional cloning of the mouse obese gene and its human homologue - PubMed

Affiliations

• PMID: 7984236
• DOI: 10.1038/372425a0

Positional cloning of the mouse obese gene and its human homologue

Y Zhang et al. Nature. 1994.

Erratum in

• Nature 1995 Mar 30;374(6521):479

Abstract

The mechanisms that balance food intake and energy expenditure determine who will be obese and who will be lean. One of the molecules that regulates energy balance in the mouse is the obese (ob) gene. Mutation of ob results in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans. The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot.

Comment in

• Another obese gene function.

  Nakamura MT. Nakamura MT. Nature. 1995 Mar 9;374(6518):124. doi: 10.1038/374124a0. Nature. 1995. PMID: 7877681 No abstract available.

• Genetics. In search of a satiety factor.

  Rink TJ. Rink TJ. Nature. 1994 Dec 1;372(6505):406-7. doi: 10.1038/372406a0. Nature. 1994. PMID: 7984230 No abstract available.

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