Molecular analysis of mouse Rab11b: a new type of mammalian YPT/Rab protein - PubMed

Comparative Study

Molecular analysis of mouse Rab11b: a new type of mammalian YPT/Rab protein

F Lai et al. Genomics. 1994 Aug.

Abstract

Since the realization that the vesicular transport machinery is conserved from yeast to vertebrate neurons, much interest in the proteins involved has been generated. Here we describe a new type of mammalian YPT/Rab protein, named Rab11b, that is most abundantly expressed in brain, heart, and testis. It has all the hallmarks of a YPT3/Rab11 protein, but is more closely related to a ypt3-related gene isolated from fish (97% homology) than to the previously described four mammalian Rab11 genes (89% homology). The mammalian Rab11 genes discovered previously are, by contrast, 100% identical to each other. The genomic structure of a mammalian Rab11 protein is described for the first time. It is surprisingly asymmetrical, with 96% of the coding sequence contained in one-third of the transcription unit. Two copies of this gene are mapped to mouse chromosomes 1 and 17. The fine structural analysis of Rab11b and the protein sequence comparison provides a close look at all YPT3/Rab11-related genes cloned so far and clues to their possible relationship.

Similar articles

• The Ncypt1 gene from Neurospora crassa is located on chromosome 2: molecular cloning and structural analysis.

  Heintz K, Palme K, Diefenthal T, Russo VE. Heintz K, et al. Mol Gen Genet. 1992 Nov;235(2-3):413-21. doi: 10.1007/BF00279388. Mol Gen Genet. 1992. PMID: 1361212

• Cloning and characterization of a Dictyostelium gene encoding a small GTPase of the Rab11 family.

  Dragoi IA, O'Halloran TJ. Dragoi IA, et al. J Cell Biochem. 1998 Jul 1;70(1):29-37. J Cell Biochem. 1998. PMID: 9632105

• A yeast GTPase-activating protein that interacts specifically with a member of the Ypt/Rab family.

  Strom M, Vollmer P, Tan TJ, Gallwitz D. Strom M, et al. Nature. 1993 Feb 25;361(6414):736-9. doi: 10.1038/361736a0. Nature. 1993. PMID: 8441469

• Molecular characterization of tobacco cDNAs encoding two small GTP-binding proteins.

  Dallmann G, Sticher L, Marshallsay C, Nagy F. Dallmann G, et al. Plant Mol Biol. 1992 Aug;19(5):847-57. doi: 10.1007/BF00027080. Plant Mol Biol. 1992. PMID: 1643285

• Rab11 proteins in health and disease.

  Kelly EE, Horgan CP, McCaffrey MW. Kelly EE, et al. Biochem Soc Trans. 2012 Dec 1;40(6):1360-7. doi: 10.1042/BST20120157. Biochem Soc Trans. 2012. PMID: 23176481 Review.

Cited by

• Myosin vb is associated with plasma membrane recycling systems.

  Lapierre LA, Kumar R, Hales CM, Navarre J, Bhartur SG, Burnette JO, Provance DW Jr, Mercer JA, Bähler M, Goldenring JR. Lapierre LA, et al. Mol Biol Cell. 2001 Jun;12(6):1843-57. doi: 10.1091/mbc.12.6.1843. Mol Biol Cell. 2001. PMID: 11408590 Free PMC article.

• Rab11 is required for trans-golgi network-to-plasma membrane transport and a preferential target for GDP dissociation inhibitor.

  Chen W, Feng Y, Chen D, Wandinger-Ness A. Chen W, et al. Mol Biol Cell. 1998 Nov;9(11):3241-57. doi: 10.1091/mbc.9.11.3241. Mol Biol Cell. 1998. PMID: 9802909 Free PMC article.

• Emerging concepts involving inhibitory and activating RNA functionalization towards the understanding of microcephaly phenotypes and brain diseases in humans.

  Tokunaga M, Imamura T. Tokunaga M, et al. Front Cell Dev Biol. 2023 Jun 20;11:1168072. doi: 10.3389/fcell.2023.1168072. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 37408531 Free PMC article. Review.

• Rab11b regulates the trafficking and recycling of the epithelial sodium channel (ENaC).

  Butterworth MB, Edinger RS, Silvis MR, Gallo LI, Liang X, Apodaca G, Frizzell RA, Johnson JP. Butterworth MB, et al. Am J Physiol Renal Physiol. 2012 Mar 1;302(5):F581-90. doi: 10.1152/ajprenal.00304.2011. Epub 2011 Nov 30. Am J Physiol Renal Physiol. 2012. PMID: 22129970 Free PMC article.

• Exploring RAB11A Pathway to Hinder Chronic Myeloid Leukemia-Induced Angiogenesis In Vivo.

  Roma-Rodrigues C, Fernandes AR, Baptista PV. Roma-Rodrigues C, et al. Pharmaceutics. 2023 Feb 23;15(3):742. doi: 10.3390/pharmaceutics15030742. Pharmaceutics. 2023. PMID: 36986603 Free PMC article.

Publication types

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database

• Molecular Biology Databases

  • GlyGen glycoinformatics resource
  • Mouse Genome Informatics (MGI)