Regulation of granulocyte colony-stimulating factor gene expression by interleukin-17 - PubMed

Regulation of granulocyte colony-stimulating factor gene expression by interleukin-17

X Y Cai et al. Immunol Lett. 1998 May.

Abstract

Interleukin-17 (IL-17) has been previously reported to induce stromal cells to produce a number of hematopoietic and proinflammatory cytokines, including granulocyte colony-stimulating factor (G-CSF). Here, we have evaluated the mechanisms responsible for the augmentation of G-CSF gene expression by IL-17, using the murine 3T3 fibroblast cell line. Treatment of 3T3 cells, but not primary bone marrow-derived macrophages or murine monocyte/macrophage cell lines, resulted in increased steady-state G-CSF mRNA levels within 2-4 h and augmented G-CSF protein production. The combination of IL-17 and LPS enhanced G-CSF expression in an additive fashion. Stability studies revealed that IL-17 stabilized G-CSF mRNA levels, with a t1/2 of 4 h, compared to a t1/2 of less than 2 h in medium or LPS-treated cells. Induction of G-CSF expression in 3T3 cells by IL-17 did not appear to require tyrosine kinase activation or de novo protein synthesis. These studies indicate that post-transcriptional mechanisms play an important role in IL-17-induced G-CSF expression in fibroblasts and suggest that IL-17 may be useful for further delineating mechanisms of G-CSF gene regulation.

Similar articles

• Production of human granulocyte colony stimulating factor by various kinds of stromal cells in vitro detected by enzyme immunoassay and in situ hybridization.

  Watari K, Ozawa K, Tajika K, Tojo A, Tani K, Kamachi S, Harigaya K, Takahashi T, Sekiguchi S, Nagata S, et al. Watari K, et al. Stem Cells. 1994 Jul;12(4):416-23. doi: 10.1002/stem.5530120409. Stem Cells. 1994. PMID: 7524894

• Cytokine expression from bone marrow derived macrophages.

  Temeles DS, McGrath HE, Kittler EL, Shadduck RK, Kister VK, Crittenden RB, Turner BL, Quesenberry PJ. Temeles DS, et al. Exp Hematol. 1993 Feb;21(2):388-93. Exp Hematol. 1993. PMID: 7678817

• Modulation of endotoxin-induced histamine synthesis by cytokines in mouse bone marrow-derived macrophages.

  Takamatsu S, Nakashima I, Nakano K. Takamatsu S, et al. J Immunol. 1996 Jan 15;156(2):778-85. J Immunol. 1996. PMID: 8543833

• Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells.

  Drexler HG. Drexler HG. Leukemia. 1996 Apr;10(4):588-99. Leukemia. 1996. PMID: 8618433 Review.

Cited by

• Th17 cytokines and host-pathogen interactions at the mucosa: dichotomies of help and harm.

  Liu JZ, Pezeshki M, Raffatellu M. Liu JZ, et al. Cytokine. 2009 Oct-Nov;48(1-2):156-60. doi: 10.1016/j.cyto.2009.07.005. Epub 2009 Aug 7. Cytokine. 2009. PMID: 19665391 Free PMC article. Review.

• Therapeutic antibodies that target inflammatory cytokines in autoimmune diseases.

  Lai Y, Dong C. Lai Y, et al. Int Immunol. 2016 Apr;28(4):181-8. doi: 10.1093/intimm/dxv063. Epub 2015 Nov 6. Int Immunol. 2016. PMID: 26545932 Free PMC article. Review.

• The multifaceted effects of granulocyte colony-stimulating factor in immunomodulation and potential roles in intestinal immune homeostasis.

  Martins A, Han J, Kim SO. Martins A, et al. IUBMB Life. 2010 Aug;62(8):611-7. doi: 10.1002/iub.361. IUBMB Life. 2010. PMID: 20681025 Free PMC article. Review.

• The Relapse of Psoriasis: Mechanisms and Mysteries.

  Tian D, Lai Y. Tian D, et al. JID Innov. 2022 Mar 9;2(3):100116. doi: 10.1016/j.xjidi.2022.100116. eCollection 2022 May. JID Innov. 2022. PMID: 35601055 Free PMC article. Review.

• IL-17A and TNF-α Increase the Expression of the Antiapoptotic Adhesion Molecule Amigo-2 in Arthritis Synoviocytes.

  Benedetti G, Bonaventura P, Lavocat F, Miossec P. Benedetti G, et al. Front Immunol. 2016 Jun 27;7:254. doi: 10.3389/fimmu.2016.00254. eCollection 2016. Front Immunol. 2016. PMID: 27446084 Free PMC article.

MeSH terms

Substances

LinkOut - more resources

• Full Text Sources

  • Elsevier Science

• Other Literature Sources

  • The Lens - Patent Citations Database