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History
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Orica
Orica Limited Type Public (ASX: ORI) Industry Mining Services Founded Australia Headquarters Melbourne, Australia Key people Peter Duncan (Chairman, Non Exec. Director) Graeme Liebelt (Managing...
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Virginia Gregg
Infobox actor birthname = Virginia Gregg Burket caption = birthdate = birth date|1916|3|6 birthplace = Harrisburg, Illinois, U.S. deathdate = death date and age|1986|9|15|1916|3|6 deathplace = Encino, CaliforniaVirginia Gregg Burket (March 6,…
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TW200611704A - Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions - Google Patents
The present invention provides novel human glucagon-like peptide-1 (GLP-1)-receptor modulators that have biological activity similar or superior to native GLP-1 peptide and thus are useful for the treatment or prevention of diseases or disorders associated with GLP activity. Further, the present invention provides novel, chemically modified peptides that not only stimulate insulin secretion in type II diabetics, but also produce other beneficial insulinotropic responses. These synthetic peptide GLP-1 receptor modulators exhibit increased stability to proteolytic cleavage making them ideal therapeutic candidates for oral or parenteral administration. The peptides of this invention show desirable pharmacokinetic properties and desirable potency in efficacy models of diabetes.