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History
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The effect of natural and surgical menopause on the secretion of cytokines from human blood monocytes - Osteoporosis International
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Opera News
You deserve a better browser Opera's free VPN, Ad blocker, and Flow file sharing. Just a few of the must-have features built into Opera for faster, smoother and distraction-free browsing...
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The Tunnel of Eupalinos
(by Dan Hughes, with appendix by Hans J. Keller) I've just had a small but splendid adventure, the recounting of which requires some background that will take up the beginning of this story. It all took...
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4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration - Acta Neuropathologica
To address the need for more meaningful biomarkers of tauopathies, we have developed an ultrasensitive tau seed amplification assay (4R RT-QuIC) for the 4-repeat (4R) tau aggregates of progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and other diseases with 4R tauopathy. The assay detected seeds in 106–109-fold dilutions of 4R tauopathy brain tissue but was orders of magnitude less responsive to brain with other types of tauopathy, such as from Alzheimer’s disease cases. The analytical sensitivity for synthetic 4R tau fibrils was ~ 50 fM or 2 fg/sample. A novel dimension of this tau RT-QuIC testing was the identification of three disease-associated classes of 4R tau seeds; these classes were revealed by conformational variations in the in vitro amplified tau fibrils as detected by thioflavin T fluorescence amplitudes and FTIR spectroscopy. Tau seeds were detected in postmortem cerebrospinal fluid (CSF) from all neuropathologically confirmed PSP and CBD cases but not in controls. CSF from living subjects had weaker seeding activities; however, mean assay responses for cases clinically diagnosed as PSP and CBD/corticobasal syndrome were significantly higher than those from control cases. Altogether, 4R RT-QuIC provides a practical cell-free method of detecting and subtyping pathologic 4R tau aggregates as biomarkers.
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Conway's Game of Life - Javascript/Canvas Implementation
What is this? This page contains a Javascript implementation of the well know John Conway's Game of Life. It uses the List Life algorithm (by Tony Finch) and a Canvas interface for...
