Conformational analysis of bacitracin A, a naturally occurring lariat | Semantic Scholar

It is instructive to discuss the effect of metal ions or cofactors on the conformational changes of proteins prior to and during their actions, and by comparing the folding of metallopeptides and metalloproteins to those whose conformations take place in the absence ofMetal ions can provide further structural and functional information on the metal ions in the former molecules.

Although most antibiotics do not need metal ions for their biological activities, there are a number of antibiotics that require metal ions to function properly, such as bleomycin, streptonigrin, and bacitracin, which are the title subjects of this review.