Which clinical sign of Parkinson's disease best reflects the nigrostriatal lesion? | Semantic Scholar

Molecular imaging techniques may provide insights into pathophysiologic mechanisms such as neuroinflammation or abnormal protein deposition and while a potentially invaluable complement in assessing the presence and severity of dopaminergic dysfunction, these techniques are not a substitute for careful clinical assessment and other objective measures of PD severity.

The abilities of functional imaging modalities such as positron-emission tomography and single photon-emissions computed tomography to evaluate disease progression in PD will be reviewed, with special emphasis on the potential use of these modalities in the assessment of neuroprotective and/or therapeutic strategies.

The abilities of functional imaging modalities such as positron-emission tomography and single photon-emissions computed tomography to evaluate disease progression in PD will be reviewed, with special emphasis on the potential use of these modalities in the assessment of neuroprotective and/or therapeutic strategies.