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Molecular Biology of Aging | Semantic Scholar

HSP70 in Aging

The reduction of HSP70 inducibility most likely reflects the launch of a special genetic program aimed at the activation of JNK-dependent apoptosis and the destruction of old cells, which have accumulated damaged proteins and dangerous mutations.

Oxidative stress and aging in Caenorhabditis elegans.

The cloned mev-1 gene is found to be the previously sequenced gene (cyt-1) that encodes succinate dehydrogenase cytochrome b, and data suggest that CYT-1 directly participates in electron transport from FADH2 to coenzyme Q.

The Werner Syndrome: A Model for the Study of Human Aging

Recent evidence, summarized in this review, suggests specific bio‐chemical roles for this multifaceted protein WRN functions as a DNA helicase, and the interaction of WRN protein with RPA (replication protein A and p53 will undoubtedly direct efforts to further dissect the genetic pathway(s) in which WRNprotein functions in DNA metabolism and will help to unravel its contribution to the human aging process.

The aging process.

It is not unreasonable to expect on the basis of present data that the healthy life span can be increased by 5-10 or more years by keeping body weight down, at a level compatible with a sense of well-being, while ingesting diets adequate in essential nutrients but designed to minimize random free radical reactions in the body.