Extracts from “Clinical Evidence”: Trachoma | Semantic Scholar

Tetracyclines, macrolides and quinolones remain the antimicrobials of choice for the treatment of infections due to Chlamydiaceae.

A historical review of two neglected tropical diseases, namely, onchocerciasis and trachoma, both which were successfully eliminated in Mexico, demonstrates that these were worthwhile health interventions.

The bacterial affinities of these agents lend plausibility to the idea that allergic reactions similar to those induced by bacteria may play an important role in pathogenesis, particularly in subacute or chronic infections.

The existing literature on the application of natural compounds for controlling trachoma and inhibiting chlamydial bacteria is summarized and the potential for the development of new treatment modalities is explored.

Although antibiotic treatments clearly have an effect at 6 months, it was unable to show that this effect persisted at 12 months; in fact, long-term gains may be due to a secular trend in the area.

Implementing proper personal hygiene and environmental improvement measures for the control of infection transmission will be essential in reducing the potentially devastating results of trachoma infections.

TF, nucleic acid, and age-specific antibody prevalence collectively indicate that high levels of C. trachomatis transmission among children present a high risk of ocular damage due to trachoma.

The etiologic agent, a member of the Psittacosis-Lymphogranuloma-trachoma-Trachoma group (Chlamydiae), is not a virus and can be inhibited by many antimicrobial drugs in laboratory models.

Clear evidence of clustering of trachoma by village, and within village, by neighbourhood, and by neighbourhood was found, and persisted even after accounting for differences in distance to water, local religion, and proportion of children with unclean faces.

The trachoma in the doxycycline-treated children improved markedly, as compared to those receiving placebo (P), and the study was carried out double-blind, with randomized placebo controls.

Trachoma is a condition of chronic conjunctivitis caused by ocular infection with Chlamydia trachomatis that has largely disappeared from the Americas and Europe but remains hyperendemic in many areas of Africa Asia and the Middle East.

1-6 doses of azithromycin were equivalent to 30 days of topical oxytetracycline/polymyxin ointment and may offer an effective alternative means of controlling endemic trachoma.

While there was no marked difference between the efficacy of these 2 regimens of mass chemotherapy, the monthly intermittent therapy with a single dose of doxycycline offers the advantage of being more practical and less expensive for mass control of trachoma by requiring approximately one-tenth of the staff, transport, and other facilities required for the intermittent topical therapy with tetracycline eye ointment.

The present double-blind study was undertaken to assess the value of topical Gantrisin (sulphafurazole) and oral Madribon (sULphadimethoxine) tablets, alone or in combination, in trachomatous schoolchildren, using different schedules of administration.