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Nonhuman Primate Testing of the Impact of Different Regulatory T Cell Depletion Strategies on Reactivation and Clearance of Latent Simian Immunodeficiency Virus | Semantic Scholar

@article{Sivanandham2020NonhumanPT,
  title={Nonhuman Primate Testing of the Impact of Different Regulatory T Cell Depletion Strategies on Reactivation and Clearance of Latent Simian Immunodeficiency Virus},
  author={Ranjit Sivanandham and Adam J. Kleinman and Paola Sette and Egidio Brocca-Cofano and Sindhuja Murali Kilapandal Venkatraman and Benjamin B. Policicchio and Tianyu He and Cuiling Xu and Julia Swarthout and Zhirui Wang and Ivona Pandrea and Cristian Apetrei},
  journal={Journal of Virology},
  year={2020},
  volume={94},
  url={https://api.semanticscholar.org/CorpusID:220579402}
}

Treg depletion appears to be a valid intervention toward an HIV cure, reducing the size of the reservoir, reactivating the virus, and boosting cell-mediated immune responses, and the side effects in the presence of ART prevent their clinical use and call for different Treg depletion approaches.

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