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Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood | Semantic Scholar

@article{Clark2007PlateletTA,
  title={Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood},
  author={Stephen R. Clark and Adrienne C. Ma and Samantha A. Tavener and Braedon McDonald and Zahra Goodarzi and Margaret M. Kelly and Kamala D Patel and Subhadeep Chakrabarti and Erin F. McAvoy and Gary D. Sinclair and Elizabeth Keys and Emma Allen-Vercoe and Rebekah Devinney and Christopher James Doig and Francis H. Y. Green and Paul Kubes},
  journal={Nature Medicine},
  year={2007},
  volume={13},
  pages={463-469},
  url={https://api.semanticscholar.org/CorpusID:22372863}
}

It is proposed that platelet TLR4 is a threshold switch for this new bacterial trapping mechanism in severe sepsis, where NETs have the greatest capacity for bacterial trapping.

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Platelets play a direct role in sepsis-associated endothelial cell death

It is proposed that platelet CD40L-endothelial cell CD40 interactions may be important in mediating these internal death events by perhaps bypassing FasL/Fas interactions and may directly contribute to vasculitis and thrombus formation by inducing endothelial cell apoptosis and exposing the underlying extracellular matrix.

39 References