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Antitumor Activity of an EpCAM/CD3-bispecific BiTE Antibody During Long-term Treatment of Mice in the Absence of T-cell Anergy and Sustained Cytokine Release | Semantic Scholar

@article{Amann2009AntitumorAO,
  title={Antitumor Activity of an EpCAM/CD3-bispecific BiTE Antibody During Long-term Treatment of Mice in the Absence of T-cell Anergy and Sustained Cytokine Release},
  author={Maria Amann and Sandrine d'Argouges and Grit Lorenczewski and Klaus Brischwein and Roman Kischel and Ralf Lutterbuese and Susanne Mangold and Doris Rau and Jörg Volkland and Stefan Pflanz and Tobias Raum and Markus M{\"u}nz and Peter Kufer and Bernd Schlereth and Patrick A. Baeuerle and Matthias Friedrich},
  journal={Journal of Immunotherapy},
  year={2009},
  volume={32},
  pages={452-464},
  url={https://api.semanticscholar.org/CorpusID:25568468}
}

It is shown that muS 110 and MT110 recognize orthologous epitopes on mouse and human EpCAM proteins, suggesting that the target-related safety profile of muS110 in mice may be predictive for MT110 in humans.

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