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[PDF] A SNP in the ABCC11 gene is the determinant of human earwax type | Semantic Scholar

@article{Yoshiura2006ASI,
  title={A SNP in the ABCC11 gene is the determinant of human earwax type},
  author={Koh-ichiro Yoshiura and Akira Kinoshita and Takafumi Ishida and Aya Ninokata and Toshihisa Ishikawa and Tadashi Kaname and Makoto Bannai and Katsushi Tokunaga and Shunro Sonoda and Ryo Komaki and Makoto Ihara and Vladimir A Saenko and Gabit Alipov and Ichiro Sekine and Kazuki Komatsu and Haruo Takahashi and Mitsuko Nakashima and Nadiya Sosonkina and Christophe Kamungu Mapendano and Mohsen Ghadami and Masayo Nomura and Desheng Liang and Nobutomo Miwa and Dae-Kwang Kim and Ariuntuul Garidkhuu and Nagato Natsume and Tohru Ohta and Hiro-aki Tomita and Akira Kaneko and Mihoko Kikuchi and Graciela Russomando and Kenji Hirayama and Minaka Ishibashi and Aya Takahashi and Naruya Saitou and Jeffery C. Murray and Susumu Saito and Yusuke Nakamura and Norio Niikawa},
  journal={Nature Genetics},
  year={2006},
  volume={38},
  pages={324-330},
  url={https://api.semanticscholar.org/CorpusID:3201966}
}

It is shown that a SNP, 538G → A (rs17822931), in the ABCC11 gene is responsible for determination of earwax type, and this is the first example of DNA polymorphism determining a visible genetic trait.

252 Citations

31 References

The dimorphism in human normal cerumen *

It was shown that the ear‐wax types are apparently determined by a simple genetic mechanism, and can be used as a polymorphic system for both genetics and anthropology, and certain metabolic processes through which individuals with different types of oerumen may display different reactions to environmental changes.

A haplotype map of the human genome

A public database of common variation in the human genome: more than one million single nucleotide polymorphisms for which accurate and complete genotypes have been obtained in 269 DNA samples from four populations, including ten 500-kilobase regions in which essentially all information about common DNA variation has been extracted.