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@article{Hinterberger2010AutonomousRO,
  title={Autonomous role of medullary thymic epithelial cells in central CD4+ T cell tolerance},
  author={Maria Hinterberger and Martin Aichinger and Olivia Prazeres da Costa and David Voehringer and Reinhard W. Hoffmann and Ludger Klein},
  journal={Nature Immunology},
  year={2010},
  volume={11},
  pages={512-519},
  url={https://api.semanticscholar.org/CorpusID:33154019}
}

The authors' data document an autonomous contribution of mTECs to both dominant and recessive mechanisms of CD4+ T cell tolerance and support an avidity model of Treg cell development versus deletion.

262 Citations

The role of the thymic medulla in T cell development and tolerance induction

Using a novel approach based on chemokine receptor expression, stages in the positive selection process are mapped, and a model to study αβT cell development in the absence of medullary thymic epithelial cells (mTEC) is developed, highlighting differences in the developmental requirements of conventional and regulatory CD4+ T cells.

55 References