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Current status of leprosy: Epidemiology, basic science and clinical perspectives | Semantic Scholar

An Update on the Epidemiology, Diagnosis and Treatment of Leprosy

    Medicine

    Hansen's Disease - The Forgotten and Neglected…

  • 2019

The prevalence of this ancient disease is declining in most around the world and this decline is a direct effect of widespread adminis tration by public health workers of multidrug therapy, however, emerging despite the use of multi-drug therapy, identifying and monitoring resistance are still necessary.

On the Origin of Leprosy

Using comparative genomics, it is demonstrated that all extant cases of leprosy are attributable to a single clone whose dissemination worldwide can be retraced from analysis of very rare single-nucleotide polymorphisms.

Relapse in leprosy.

Clinicians may need to use their judgement to modify the standard WHO treatment regimens according to the scenario in each patient, and factors that should be considered are the type of leprosy (PB or MB), previous treatment and drug resistance.

The management of leprosy reversal reactions.

Although patients with the polar TT and LL forms of the disease are generally stable, in the absence of therapy there is a gradual decline in the cellular immune response in the majority of patients, so that they downgrade to a more lepromatous form of disease.