Activation of Endothelial Cell Protease Activated Receptor 1 by the Protein C Pathway | Semantic Scholar

This review summarizes the current knowledge about interactions of APC with cell surface-associated receptors, novel substrates such as histones and tissue factor pathway inhibitor, and their implications for the biologic function ofAPC in the control of coagulation and inflammation.

Activation of the coagulation cascade and the downstream endothelial cell localized anticoagulant pathway thus have opposing effects on systemic inflammation, and this dichotomy is of relevance for the interpretation of preclinical and clinical data that document nonuniform responses to anticoAGulant strategies in sepsis therapy.