Bcl-2 associates with the ras-related protein R-rasp23 | Semantic Scholar

The role of activated bcl-2 in follicular lymphoma provided direct evidence that suppression of apoptosis contributes to tumourigenesis and revealed a new class of aberrant signals in cancer cells that contributes to their unrestrained proliferation.

To delineate the contribution of these two oncogenes to factor-independent growth, 32D cells constitutively expressing v-myc or v-raf were established and analyzed in the presence or absence of the growth factor IL-3.