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Requirement for Xist in X chromosome inactivation | Semantic Scholar

@article{Penny1996RequirementFX,
  title={Requirement for Xist in X chromosome inactivation},
  author={Graeme D. Penny and Graham F. Kay and Steven A. Sheardown and Sohaila Rastan and Neil Brockdorff},
  journal={Nature},
  year={1996},
  volume={379},
  pages={131-137},
  url={https://api.semanticscholar.org/CorpusID:4329368}
}

Evidence for gene targeting of Xist, the proposed candidate for the X inactivation centre, is provided, and its absolute requirement in the process of X chromosome inactivation is provided.

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Mechanisms of X‐inactivation

X-inactivation involves the transcriptional silencing of one of the two X-chromosomes in the cells of female mammals. This process is controlled by elements present in the X-inactivation centre (Xic)…

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