Molecular and biological characterization of a murine ligand for CD40 | Semantic Scholar

Functional data such as these led to the search for studies using monoclonal antibodies to CD40 which indicated a diverse array of biological activities occurs as a result of signaling through CD40.

As other members of the tumor necrosis factor receptor family have been shown to bind several ligands, it is possible that CD40 may bind other ligands that may trigger CD40 on different cell types such as hematopoietic cells or epithelial cells.