Tumour suppression: Disruption of HAUSP gene stabilizes p53 | Semantic Scholar

It is demonstrated that MDM2, rather than p53, is the substrate for HAUSP under physiologic conditions and a fascinating and unexpected twist to the regulation of the p53/MDM2 axis is document.

It is shown that inhibitors ofHAUSP and Nutlin-3 can synergistically activate p53 function and induce p53-dependent apoptosis in human cancer cells and that newly synthesized HAUSP inhibitors are more potent than the commercially available inhibitors to suppress N-Myc activities in p53 mutant cells for growth suppression.