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TPL-2 kinase regulates the proteolysis of the NF-κB-inhibitory protein NF-κB1 p105 | Semantic Scholar

@article{Belich1999TPL2KR,
  title={TPL-2 kinase regulates the proteolysis of the NF-$\kappa$B-inhibitory protein NF-$\kappa$B1 p105},
  author={M{\^o}nica P. Belich and Andres Salmeron and Leland H. Johnston and Steven C. Ley},
  journal={Nature},
  year={1999},
  volume={397},
  pages={363-368},
  url={https://api.semanticscholar.org/CorpusID:4391108}
}

TPL-2 is a component of a new signalling pathway that controls proteolysis of NF-κB1 p105 and blocks the degradation of p105 induced by tumour-necrosis factor-α.

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30 References

Proteolytic Processing of NF-B/IB in Human Monocytes

It is demonstrated that, following stimulation of human monocytic cells with lipopolysaccharide or tumor necrosis factor-α, this critical p105 processing event is up-regulated in concert with the inactivation of IκBα, providing direct biochemical evidence that p105 and IκBs are differentially sensitive targets for inducible proteolysis via ATP-dependent degradative pathways.