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Psychedelics and Anti-inflammatory Activity in Animal Models

  • ️Thu May 12 2022
  • Adams AM et al (2019) In vivo production of psilocybin in E. coli. Metab Eng 56:111–119

    Article  CAS  Google Scholar 

  • Afshar S, Shahidi S, Rohani AH, Soleimani Asl S, Komaki A (2019) Protective effects of 5-HT(1A) receptor antagonist and 5-HT(2A) receptor agonist on the biochemical and histological features in a rat model of Alzheimer's disease. J Chem Neuroanat 96:140–147. https://doi.org/10.1016/j.jchemneu.2019.01.008

    Article  CAS  PubMed  Google Scholar 

  • Akiyoshi T et al (2006) Induction of indefinite survival of fully mismatched cardiac allografts and generation of regulatory cells by sarpogrelate hydrochloride. Transplantation 82:1051–1059. https://doi.org/10.1097/01.tp.0000233870.54297.9a

    Article  PubMed  Google Scholar 

  • Aldridge J, Décary-Hétu D (2016) Hidden wholesale: the drug diffusing capacity of online drug cryptomarkets. Int J Drug Policy 35:7–15

    Article  Google Scholar 

  • Arzt E, Costas M, Finkielman S, Nahmod VE (1991) Serotonin inhibition of tumor necrosis factor-alpha synthesis by human monocytes. Life Sci 48:2557–2562. https://doi.org/10.1016/0024-3205(91)90612-f

    Article  CAS  PubMed  Google Scholar 

  • Aun MV, Bonamichi-Santos R, Arantes-Costa FM, Kalil J, Giavina-Bianchi P (2017) Animal models of asthma: utility and limitations. J Asthma Allergy 10:293–301. https://doi.org/10.2147/jaa.s121092

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Barnes PJ (2006) How corticosteroids control inflammation: quintiles prize lecture 2005. Br J Pharmacol 148:245–254. https://doi.org/10.1038/sj.bjp.0706736

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Barnes PJ (2010) Inhaled corticosteroids in COPD: a controversy. Respiration 80:89–95. https://doi.org/10.1159/000315416

    Article  CAS  PubMed  Google Scholar 

  • Bates JHT, Rincon M, Irvin CG (2009) Animal models of asthma. Am J Physiol Lung Cell Mol Physiol 297:L401–L410

    Article  CAS  Google Scholar 

  • Brattelid T et al (2007) Serotonin responsiveness through 5-HT2A and 5-HT4 receptors is differentially regulated in hypertrophic and failing rat cardiac ventricle. J Mol Cell Cardiol 43:767–779. https://doi.org/10.1016/j.yjmcc.2007.08.019

    Article  CAS  PubMed  Google Scholar 

  • Canal CE, Morgan D (2012) Head-twitch response in rodents induced by the hallucinogen 2,5-dimethoxy-4-iodoamphetamine: a comprehensive history, a re-evaluation of mechanisms, and its utility as a model. Drug Test Anal 4:556–576. https://doi.org/10.1002/dta.1333

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Carhart-Harris RL et al (2016) Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study. Lancet Psychiatry 3:619–627. https://doi.org/10.1016/s2215-0366(16)30065-7

    Article  PubMed  Google Scholar 

  • Carhart-Harris RL et al (2017) Psilocybin with psychological support for treatment-resistant depression: six-month follow-up. Psychopharmacology (Berl). https://doi.org/10.1007/s00213-017-4771-x

  • Christ A et al (2018) Western diet triggers NLRP3-dependent innate immune reprogramming. Cell 172:162–175.e114. https://doi.org/10.1016/j.cell.2017.12.013

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Curtis JR, Hobar C, Hansbrough K (2011) Injection-site burning and stinging in patients with rheumatoid arthritis using injectable biologics. Curr Med Res Opin 27:71–78. https://doi.org/10.1185/03007995.2010.534959

    Article  PubMed  Google Scholar 

  • da Silva MG, Daros GC, de Bitencourt RM (2020) Anti-inflammatory activity of ayahuasca and its implications for the treatment of neurological and psychiatric diseases. Behav Brain Res 113003

    Google Scholar 

  • Davydova SM, Cheido MA, Gevorgyan MM, Idova GV (2010) Effects of 5-HT2A receptor stimulation and blocking on immune response. Bull Exp Biol Med 150:219–221

    Article  CAS  Google Scholar 

  • dos Santos RG (2014) Immunological effects of ayahuasca in humans. J Psychoactive Drugs 46:383–388

    Article  Google Scholar 

  • Du T et al (1996) Effect of nedocromil sodium on allergen-induced airway responses and changes in the quantity of airway smooth muscle in rats. J Allergy Clin Immunol 98:400–407

    Article  CAS  Google Scholar 

  • Flanagan TW, Nichols CD (2018) Psychedelics as anti-inflammatory agents. Int Rev Psychiatry:1–13. https://doi.org/10.1080/09540261.2018.1481827

  • Flanagan TW et al (2019a) Activation of 5-HT2 receptors reduces inflammation in vascular tissue and cholesterol levels in high-fat diet-fed apolipoprotein E knockout mice. Sci Rep 9:13444. https://doi.org/10.1038/s41598-019-49987-0

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Flanagan TW et al (2019b) 5-HT2 receptor activation alleviates airway inflammation and structural remodeling in a chronic mouse asthma model. Life Sci 236:116790. https://doi.org/10.1016/j.lfs.2019.116790

    Article  CAS  PubMed  Google Scholar 

  • Flanagan TW et al (2020) Structure–activity relationship analysis of psychedelics in a rat model of asthma reveals the anti-inflammatory pharmacophore. ACS Pharmacol Transl, Science

    Google Scholar 

  • Forstmann M, Sagioglou C (2020) How psychedelic researchers’ self-admitted substance use and their association with psychedelic culture affect people’s perceptions of their scientific integrity and the quality of their research. Public Underst Sci:0963662520981728

    Google Scholar 

  • Frecska E, Bokor P, Winkelman M (2016) The therapeutic potentials of ayahuasca: possible effects against various diseases of civilization. Front Pharmacol 7:35

    Article  Google Scholar 

  • Fulkerson PC, Rothenberg ME, Hogan SP (2005) Building a better mouse model: experimental models of chronic asthma. Clin Exp Allergy 35:1251–1253. https://doi.org/10.1111/j.1365-2222.2005.02354.x

    Article  CAS  PubMed  Google Scholar 

  • Galvão-Coelho NL et al (2020) Changes in inflammatory biomarkers are related to the antidepressant effects of ayahuasca. J Psychopharmacol 34:1125–1133

    Article  Google Scholar 

  • Giridharan VV et al (2020) Clozapine prevents poly (I: C) induced inflammation by modulating NLRP3 pathway in microglial cells. Cells 9

    Google Scholar 

  • Girodet PO et al (2015) Calcium channel blocker reduces airway remodeling in severe asthma. A proof-of-concept study. Am J Respir Crit Care Med 191:876–883. https://doi.org/10.1164/rccm.201410-1874OC

    Article  CAS  PubMed  Google Scholar 

  • Glennon RA, Young R, Benington F, Morin RD (1982) Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane. J Med Chem 25:1163–1168. https://doi.org/10.1021/jm00352a013

    Article  CAS  PubMed  Google Scholar 

  • Griffiths RR et al (2016) Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: a randomized double-blind trial. J Psychopharmacol 30:1181–1197. https://doi.org/10.1177/0269881116675513

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Harbuz MS et al (1996) The role of endogenous serotonin in adjuvant-induced arthritis in the rat. Br J Rheumatol 35:112–116

    Article  CAS  Google Scholar 

  • Harbuz MS, Marti O, Lightman SL, Jessop DS (1998) Alteration of central serotonin modifies onset and severity of adjuvant-induced arthritis in the rat. Br J Rheumatol 37:1077–1083

    Article  CAS  Google Scholar 

  • Hawiger JJN, Veach RA, Zienkiewicz J, Liu Y, Collins RD, Major AS (2018) Compositions and methods for treating and preventing hyperlipidemia, fatty liver, atherosclerosis and other disorders associated with metabolic syndrome. United States patent

    Google Scholar 

  • Hayashi T et al (2003) Sarpogrelate HCl, a selective 5-HT2A antagonist, retards the progression of atherosclerosis through a novel mechanism. Atherosclerosis 168:23–31

    Article  CAS  Google Scholar 

  • Hong Y, Ji H, Wei H (2006) Topical ketanserin attenuates hyperalgesia and inflammation in arthritis in rats. Pain 124:27–33

    Article  CAS  Google Scholar 

  • Hope DB, Smith AD (1960) Distribution and activity of monoamine oxidase in mouse tissues. Biochem J 74:101–107

    Article  CAS  Google Scholar 

  • Hori A, Nishida T, Takashiba S, Kubota S, Takigawa M (2017) Regulatory mechanism of CCN2 production by serotonin (5-HT) via 5-HT2A and 5-HT2B receptors in chondrocytes. PLoS One 12:e0188014. https://doi.org/10.1371/journal.pone.0188014

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hoshino M, Takahashi M, Takai Y, Sim J (1999) Inhaled corticosteroids decrease subepithelial collagen deposition by modulation of the balance between matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in asthma. J Allergy Clin Immunol 104:356–363

    Article  CAS  Google Scholar 

  • Hu X et al (2012) Clozapine protects dopaminergic neurons from inflammation-induced damage by inhibiting microglial overactivation. J Neuroimmune Pharmacol 7:187–201

    Article  Google Scholar 

  • Hunt DA, Keefe J, Whitehead T (2021) Understanding cannabis: clinical considerations. J Nurse Pract 17:163–167

    Article  Google Scholar 

  • Hutcheson JD, Setola V, Roth BL, Merryman WD (2011) Serotonin receptors and heart valve disease – it was meant 2B. Pharmacol Ther 132:146–157. https://doi.org/10.1016/j.pharmthera.2011.03.008

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Inoue M et al (2011) Regulation of antigen-specific CTL and Th1 cell activation through 5-hydroxytryptamine 2A receptor. Int Immunopharmacol 11:67–73. https://doi.org/10.1016/j.intimp.2010.10.007

    Article  CAS  PubMed  Google Scholar 

  • Inserra A, De Gregorio D, Gobbi G (2021) Psychedelics in psychiatry: neuroplastic, immunomodulatory, and neurotransmitter mechanisms. Pharmacol Rev 73:202–277. https://doi.org/10.1124/pharmrev.120.000056

    Article  CAS  PubMed  Google Scholar 

  • Ishiwata K, Kobayashi T, Kawamura K, Matsuno K (2003) Age-related changes of the binding of [3h]SA4503 to sigma1 receptors in the rat brain. Ann Nucl Med 17:73–77

    Article  CAS  Google Scholar 

  • Joubert AI et al (2020) Mechanisms of particles in sensitization, effector function and therapy of allergic disease. Front Immunol 11:1334

    Article  CAS  Google Scholar 

  • Kaur G, Krishan P (2020) Serotonin 5HT(2A) receptor antagonism mediated anti-inflammatory and anti-fibrotic effect in adriamycin-induced CKD in rats. Naunyn Schmiedebergs Arch Pharmacol 393:1269–1279. https://doi.org/10.1007/s00210-020-01826-0

    Article  CAS  PubMed  Google Scholar 

  • Kobayashi T et al (2014) Matrix metalloproteinase-9 activates TGF-beta and stimulates fibroblast contraction of collagen gels. Am J Physiol Lung Cell Mol Physiol 306:L1006–L1015. https://doi.org/10.1152/ajplung.00015.2014

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kodela R, Chattopadhyay M, Kashfi K (2012) NOSH-aspirin: a novel nitric oxide-hydrogen Sulfide-releasing hybrid: a new class of anti-inflammatory pharmaceuticals. ACS Med Chem Lett 3:257–262. https://doi.org/10.1021/ml300002m

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Koeberle A, Laufer SA, Werz O (2016) Design and development of microsomal prostaglandin E2 Synthase-1 inhibitors: challenges and future directions. J Med Chem 59:5970–5986. https://doi.org/10.1021/acs.jmedchem.5b01750

    Article  CAS  PubMed  Google Scholar 

  • Kuypers KPC et al (2019) Microdosing psychedelics: more questions than answers? An overview and suggestions for future research. J Psychopharmacol 33:1039–1057

    Article  CAS  Google Scholar 

  • Kyzar EJ, Nichols CD, Gainetdinov RR, Nichols DE, Kalueff AV (2017) Psychedelic drugs in biomedicine. Trends Pharmacol Sci 38:992–1005. https://doi.org/10.1016/j.tips.2017.08.003

    Article  CAS  PubMed  Google Scholar 

  • Li P, Zheng Y, Chen X (2017) Drugs for autoimmune inflammatory diseases: from small molecule compounds to anti-TNF biologics. Front Pharmacol 8:460. https://doi.org/10.3389/fphar.2017.00460

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Londesbrough DJ et al (2020) Google Patents

    Google Scholar 

  • Ma Y et al (2016) Immunization against TGF-beta1 reduces collagen deposition but increases sustained inflammation in a murine asthma model. Hum Vaccin Immunother 12:1876–1885. https://doi.org/10.1080/21645515.2016.1145849

    Article  PubMed  PubMed Central  Google Scholar 

  • Ma Y et al (2021) 5-HT(2A) receptor and 5-HT degradation play a crucial role in atherosclerosis by modulating macrophage foam cell formation, vascular endothelial cell inflammation, and hepatic steatosis. J Atheroscler Thromb. https://doi.org/10.5551/jat.58305

  • Maes M, Meltzer HY, Bosmans E (1994) Immune-inflammatory markers in schizophrenia: comparison to normal controls and effects of clozapine. Acta Psychiatr Scand 89:346–351

    Article  CAS  Google Scholar 

  • Manzel A et al (2014) Role of “Western diet” in inflammatory autoimmune diseases. Curr Allergy Asthma Rep 14:404. https://doi.org/10.1007/s11882-013-0404-6

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Marconi A, Darquenne S, Boulmerka A, Mosnier M, D'Alessio P (2003) Naftidrofuryl-driven regulation of endothelial ICAM-1 involves nitric oxide. Free Radic Biol Med 34:616–625

    Article  CAS  Google Scholar 

  • Martin DA, Marona-Lewicka D, Nichols DE, Nichols CD (2014) Chronic LSD alters gene expression profiles in the mPFC relevant to schizophrenia. Neuropharmacology 83:1–8. https://doi.org/10.1016/j.neuropharm.2014.03.013

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • McKune CM, Watts SW (2001) Characterization of the serotonin receptor mediating contraction in the mouse thoracic aorta and signal pathway coupling. J Pharmacol Exp Ther 297:88–95

    CAS  PubMed  Google Scholar 

  • Mei J, Pasternak GW (2001) Molecular cloning and pharmacological characterization of the rat sigma1 receptor. Biochem Pharmacol 62:349–355. https://doi.org/10.1016/s0006-2952(01)00666-9

    Article  CAS  PubMed  Google Scholar 

  • Moss AC (2018) Treatment of inflammatory bowel disease with biologics. Springer, pp 1–11

    Book  Google Scholar 

  • Munroe ME, Businga TR, Kline JN, Bishop GA (2010) Anti-inflammatory effects of the neurotransmitter agonist honokiol in a mouse model of allergic asthma. J Immunol 185:5586–5597. https://doi.org/10.4049/jimmunol.1000630

    Article  CAS  PubMed  Google Scholar 

  • Nagatomo T, Rashid M, Abul Muntasir H, Komiyama T (2004) Functions of 5-HT2A receptor and its antagonists in the cardiovascular system. Pharmacol Ther 104:59–81. https://doi.org/10.1016/j.pharmthera.2004.08.005

    Article  CAS  PubMed  Google Scholar 

  • Nau F Jr, Yu B, Martin D, Nichols CD (2013) Serotonin 5-HT2A receptor activation blocks TNF-alpha mediated inflammation in vivo. PLoS One 8:e75426. https://doi.org/10.1371/journal.pone.0075426

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nau F Jr et al (2015) Serotonin 5-HT(2) receptor activation prevents allergic asthma in a mouse model. Am J Physiol Lung Cell Mol Physiol 308:L191–L198. https://doi.org/10.1152/ajplung.00138.2013

    Article  CAS  PubMed  Google Scholar 

  • Nichols CD (2009) Serotonin 5-HT(2A) receptor function as a contributing factor to both neuropsychiatric and cardiovascular diseases. Cardiovasc Psychiatry Neurol 2009:475108. https://doi.org/10.1155/2009/475108

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nichols DE (2012) Structure-activity relationships of serotonin 5-HT2A agonists. In: WIRES membrane transport and signaling, vol 1, pp 559–579

    Google Scholar 

  • Nichols DE (2016) Psychedelics. Pharmacol Rev 68:264–355. https://doi.org/10.1124/pr.115.011478

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nichols DE, Johnson MW, Nichols CD (2017) Psychedelics as medicines: an emerging new paradigm. Clin Pharmacol Ther 101:209–219. https://doi.org/10.1002/cpt.557

    Article  CAS  PubMed  Google Scholar 

  • Nishiyama T (2009) Acute effects of sarpogrelate, a 5-HT2A receptor antagonist on cytokine production in endotoxin shock model of rats. Eur J Pharmacol 614:122–127. https://doi.org/10.1016/j.ejphar.2009.03.041

    Article  CAS  PubMed  Google Scholar 

  • Pierce PA, Xie GX, Peroutka SJ, Green PG, Levine JD (1995) 5-Hydroxytryptamine-induced synovial plasma extravasation is mediated via 5-hydroxytryptamine2A receptors on sympathetic efferent terminals. J Pharmacol Exp Ther 275:502–508

    CAS  PubMed  Google Scholar 

  • Pini L, Torregiani C, Martin JG, Hamid Q, Ludwig MS (2006) Airway remodeling in allergen-challenged Brown Norway rats: distribution of proteoglycans. Am J Physiol Lung Cell Mol Physiol 290:L1052–L1058. https://doi.org/10.1152/ajplung.00122.2005

    Article  CAS  PubMed  Google Scholar 

  • Qi J, Zulfiker AHM, Li C, Good D, Wei MQ (2018) The development of toad toxins as potential therapeutic agents. Toxins 10:336

    Article  Google Scholar 

  • Ramakrishnan NK et al (2016) Sigma-1 agonist binding in the aging rat brain: a MicroPET study with [(11)C]SA4503. Mol Imaging Biol 18:588–597. https://doi.org/10.1007/s11307-015-0917-6

    Article  CAS  PubMed  Google Scholar 

  • Rider P, Carmi Y, Cohen I (2016) Biologics for targeting inflammatory cytokines, clinical uses, and limitations. Int J Cell Biol 2016:9259646. https://doi.org/10.1155/2016/9259646

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rosenblum MD, Remedios KA, Abbas AK (2015) Mechanisms of human autoimmunity. J Clin Invest 125:2228–2233

    Article  Google Scholar 

  • Ross S et al (2016) Rapid and sustained symptom reduction following psilocybin treatment for anxiety and depression in patients with life-threatening cancer: a randomized controlled trial. J Psychopharmacol 30:1165–1180. https://doi.org/10.1177/0269881116675512

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Roth BL (2007) Drugs and valvular heart disease. N Engl J Med 356:6–9. https://doi.org/10.1056/NEJMp068265

    Article  CAS  PubMed  Google Scholar 

  • Rothman RB, Baumann MH (2009) Serotonergic drugs and valvular heart disease. Expert Opin Drug Saf 8:317–329. https://doi.org/10.1517/14740330902931524

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sasaki M, Obata H, Kawahara K, Saito S, Goto F (2006) Peripheral 5-HT2A receptor antagonism attenuates primary thermal hyperalgesia and secondary mechanical allodynia after thermal injury in rats. Pain 122:130–136. https://doi.org/10.1016/j.pain.2006.01.021

    Article  CAS  PubMed  Google Scholar 

  • Shen HW, Jiang XL, Winter JC, Yu AM (2010) Psychedelic 5-methoxy-N,N-dimethyltryptamine: metabolism, pharmacokinetics, drug interactions, and pharmacological actions. Curr Drug Metab 11:659–666

    Article  CAS  Google Scholar 

  • Shulgin ATS (1991) PIHKAL: a chemical love story. Transform Press

    Google Scholar 

  • Sugino H, Futamura T, Mitsumoto Y, Maeda K, Marunaka Y (2009) Atypical antipsychotics suppress production of proinflammatory cytokines and up-regulate interleukin-10 in lipopolysaccharide-treated mice. Prog Neuropsychopharmacol Biol Psychiatry 33:303–307

    Article  CAS  Google Scholar 

  • Sumino K, Sheshadri A, Castro M (2015) Calcium channel blocker reduces airway remodeling-or does it? Am J Respir Crit Care Med 191:863–864. https://doi.org/10.1164/rccm.201502-0322ED

    Article  PubMed  Google Scholar 

  • Szabo A (2015) Psychedelics and immunomodulation: novel approaches and therapeutic opportunities. Front Immunol 6:358. https://doi.org/10.3389/fimmu.2015.00358

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Szabo A, Kovacs A, Frecska E, Rajnavolgyi E (2014) Psychedelic N,N-dimethyltryptamine and 5-methoxy-N,N-dimethyltryptamine modulate innate and adaptive inflammatory responses through the sigma-1 receptor of human monocyte-derived dendritic cells. PLoS One 9:e106533. https://doi.org/10.1371/journal.pone.0106533

    Article  PubMed  PubMed Central  Google Scholar 

  • Thompson C, Szabo A (2020) Psychedelics as a novel approach to treating autoimmune conditions. Immunol Lett 228:45–54. https://doi.org/10.1016/j.imlet.2020.10.001

    Article  CAS  PubMed  Google Scholar 

  • Todorović N, Filipović D (2017) The antidepressant-and anxiolytic-like effects of fluoxetine and clozapine in chronically isolated rats involve inhibition of hippocampal TNF-α. Pharmacol Biochem Behav 163:57–65

    Article  Google Scholar 

  • Toruner M et al (2008) Risk factors for opportunistic infections in patients with inflammatory bowel disease. Gastroenterology 134:929–936. https://doi.org/10.1053/j.gastro.2008.01.012

    Article  PubMed  Google Scholar 

  • Uchida-Kitajima S et al (2008) 5-Hydroxytryptamine 2A receptor signaling cascade modulates adiponectin and plasminogen activator inhibitor 1 expression in adipose tissue. FEBS Lett 582:3037–3044. https://doi.org/10.1016/j.febslet.2008.07.044

    Article  CAS  PubMed  Google Scholar 

  • Vane JR, Botting RM (1998) Anti-inflammatory drugs and their mechanism of action. Inflamm Res 47(Suppl 2):S78–S87. https://doi.org/10.1007/s000110050284

    Article  CAS  PubMed  Google Scholar 

  • Wacker D et al (2017) Crystal structure of an LSD-bound human serotonin receptor. Cell 168:377–389.e312. https://doi.org/10.1016/j.cell.2016.12.033

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wu AC, Fuhlbrigge AL, Robayo MA, Shaker M (2020) Cost-effectiveness of biologics for allergic diseases. J Allergy Clin Immunol Pract. https://doi.org/10.1016/j.jaip.2020.10.009

  • Xu D et al (2021) Evaluation of analgesic and anti-inflammatory actions of indolealkylamines from toad venom in mice using lipidomics and molecular docking. J Ethnopharmacol 269:113677

    Article  CAS  Google Scholar 

  • Yu B et al (2008) Serotonin 5-hydroxytryptamine(2A) receptor activation suppresses tumor necrosis factor-alpha-induced inflammation with extraordinary potency. J Pharmacol Exp Ther 327:316–323. https://doi.org/10.1124/jpet.108.143461

    Article  CAS  PubMed  Google Scholar 

  • Zhang Y et al (2019) Comparative analysis of hydrophilic ingredients in toad skin and toad venom using the UHPLC-HR-MS/MS and UPLC-QqQ-MS/MS methods together with the anti-inflammatory evaluation of indolealkylamines. Molecules 24:86

    Article  Google Scholar 

  • Zosky GR, Sly PD (2007) Animal models of asthma. Clin Exp Allergy 37:973–988. https://doi.org/10.1111/j.1365-2222.2007.02740.x

    Article  CAS  PubMed  Google Scholar 

  • Zulfiker AH, Hashimi SM, Qi J, Grice ID, Wei MQ (2016) Aqueous and ethanol extracts of Australian cane toad skins suppress pro-inflammatory cytokine secretion in U937 cells via NF-kappaB Signaling pathway. J Cell Biochem 117:2769–2780. https://doi.org/10.1002/jcb.25577

    Article  CAS  PubMed  Google Scholar