Arsenic-Based Drugs: From Fowler’s Solution to Modern Anticancer Chemotherapy
- ️Fri Jan 01 2010
Ralph SJ (2008) Arsenic-based antineoplastic drugs and their mechanisms of action. Met Based Drugs 2008:260146
Li S, Luo X (2003) Compendium of materia medica. Foreign Languages Press, Beijing
Jackson R, Grainge JW (1975) Arsenic and cancer. Can Med Assoc J 113:396–401
Evens AM, Tallman MS, Gartenhaus RB (2004) The potential of arsenic trioxide in the treatment of malignant disease: past, present, and future. Leuk Res 28:891–900
Lipscomb JD (1877) Improvement in remedy for fevers. US Patent 186,141
Ramsaur MH (1869) Improved medical compound. US Patent 92,209
Lentilius R (1684) Ephémérides des curieux de la nature. Dec. 11, an 3 - Obs. 46
Friceius M (1710) Cap 2. Tractus de Virtute Venenorum Medica
Frank J (1835) Encyclopédie des Sciences Médicales ou traité général méthodique et complet des diverses branches de l'art de guérir. Deuxième division, Médecine : pathologie médicale. Bureau de l'Encyclopédie, Paris
Fowler T (1786) Medical reports on the effects of arsenic in the cure of agues, remittent fevers and perodic headaches
Hunt T (1848) Minimum fatal dose of arsenic. Prov Med Surg J 12:445
Hunt T (1848) On Dr. Castle's case of supposed poisoning by Fowler's solution. Prov Med Surg J 12:391
Bouteille B, Oukem O, Bisser S et al (2003) Treatment perspectives for human African trypanosomiasis. Fundam Clin Pharmacol 17:171–181
Steverding D (2008) The history of African trypanosomiasis. Parasit Vectors 1:3
Livingstone D (1858) Arsenic as a remedy for the tse tse bite. Br Med J 1:360–361
Manchester K (2001) Antoine Béchamp: père de la biologie. Oui ou non? Endeavour 25:68–73
Béchamp A (1863) De l'action de la chaleur sur l'arséniate d'aniline et de la formation d'un anilide de l'acide arsénique. Compt Rend 56:1172–1175
Thomas H (1905) Some experiments in the treatment of trypanosmiasis. Br Med J 1:1140–1143
Scherber G (1907) The atoxyl treatment of syphilis. Wien Klin Wochenschr 20:1165–1172
Blumenthal F (1902) Über Metaarsensäureanilid (atoxyl). Med Woche 3:163
Ehrlich P, Bertheim A (1907) Über p-Aminophenylarsinsäure. Ber Dtsch Chem Ges 40:3292–3297
Anonymous (1910) Action of Atoxyl on Eyes. Cal State J Med 8:384
Knopf H, Fabian R (1909) Further results of Atoxyl treatment. Berl Klin Wochenschr 46:99–101
Jacobs WA, Heidelberger M (1919) Aromatic arsenic compounds. II. The amides and alkylamides of N-arylglycine arsonic acids. J Am Chem Soc 41:1809–1821
Pearce L (1925) Tryparsamide treatment of African sleeping sickness. Science 61:90–92
Pearce L (1921) Treatment of human trypanosomiasis with tryparsamide (sodium salt of N-phenylglycineamide-p-arsonic acid). J Exp Med 34(1):1–104
Hawking F (1941) Drug resistance acquired during the treatment of sleeping sickness with tryparsamide and with Bayer 205. Am J Trop Med 21:469–475
Friedheim EAH (1944) Trypanocidal and spirochetocidal arsenicals derived from s-triazine. J Am Chem Soc 66:1775–1778
Friedheim EAH (1942) Substituted [1,3,5-triazinyl-(6)]-aminophenyl-arsonic acids and process for manufacture of same. US Patent 2,295,574
Doak G, Steinman H, Eagle H (1944) Arsenoso compounds containing amide groups. J Am Chem Soc 66:194–197
Banks C, Gruhzit O, Tillitson E et al (1944) Arylaminoheterocycles. III. Arsenicals of anilinotriazines. J Am Chem Soc 66:1771–1775
Jonchère H, Gomer J, Reynaud R (1953) Contribution à l'étude de produits à radical mélaminyl dans le traitement de la trypanosomiase humaine. Bull Soc Pathol Exot 46:386–396
Friedheim EAH (1948) Melarsen oxide in the treatment of human African trypanosomiasis. Ann Trop Med 42:357–363
Peters R, Stocken L, Thompson R (1945) British Anti-Lewisite (BAL). Nature 156:616–619
Friedheim EAH (1953) Heterocyclic metal and sulfur organic compounds. US Patent 2,664,432
Gibaud S, Alfonsi R, Mutzenhardt P et al (2006) (2-Phenyl-[1, 3, 2] dithiarsolan-4-yl)-methanol derivatives show in vitro antileukemic activity. J Organomet Chem 691:1081–1084
Friedheim EAH (1952) Propylene glycol solution of arsenic medicaments. US Patent 3,593,434
Watson HJC (1962) Mel W: A field trial in the treatment of Trypanosoma gambiense sleeping sickness. Trans R Soc Trop Med Hyg 56:231–235
Watson HJC (1965) Mel W: final report on a field trial in the treatment of Trypanosoma gambiense sleeping sickness. Trans R Soc Trop Med Hyg 59:163–170
Loiseau PM, Lubert P, Wolf JG (2000) Contribution of dithiol ligands to In vitro and In vivo trypanocidal activities of dithiaarsanes and investigation of ligand exchange in an aqueous solution. Antimicrob Agents Chemother 44:2954–2961
Pépin J, Milord F, Khonde A et al (1994) Gambiense trypanosomiasis: frequency of, and risk factors for, failure of melarsoprol therapy. Trans R Soc Trop Med Hyg 88:447–452
Pépin J, Milord F (1991) African trypanosomiasis and drug-induced encephalopathy: risk factors and pathogenesis. Trans R Soc Trop Med Hyg 85:222–224
Kennedy PGE (2006) Diagnostic and neuropathogenesis issues in human African trypanosomiasis. Int J Parasitol 36:505–512
Adams JH, Haller L, Boa FY et al (1986) Human African trypanosomiasis (T.b. gambiense): a study of 16 fatal cases of sleeping sickness with some observations on acute reactive arsenical encephalopathy. Neuropathol Appl Neurobiol 12:81–94
Friedheim EAH (1951) Mel B in the treatment of tryparsamide resistant T. gambiense sleeping sickness: observations on drug resistance in the trypanosomes of the French Cameroon. Am J Trop Med Hyg 31:218–226
Friedheim EAH (1949) Mel B in the treatment of human trypasonomiasis. Am J Trop Med Hyg 29:173–180
Burri C, Nkunku S, Merolle A et al (2000) Efficacy of new, concise schedule for melarsoprol in treatment of sleeping sickness caused by Trypanosoma brucei gambiense: a randomised trial. Lancet 355:1419–1425
Pépin J, Mpia B (2006) Randomized controlled trial of three regimens of melarsoprol in the treatment of Trypanosoma brucei gambiense trypanosomiasis. Trans R Soc Trop Med Hyg 100:437–441
Pépin J, Milord F, Guern C et al (1989) Trial of prednisolone for prevention of melarsoprol-induced encephalopathy in gambiense sleeping sickness. Lancet 1:1246–1250
Carter NS, Fairlamb AH (1993) Arsenical-resistant trypanosomes lack an unusual adenosine transporter. Nature 361:173–176
Balasegaram M, Young H, Chappuis F et al (2009) Effectiveness of melarsoprol and eflornithine as first-line regimens for gambiense sleeping sickness in nine Médecins Sans Frontières programmes. Trans R Soc Trop Med Hyg 103:280–290
Jennings FW (1993) Combination chemotherapy of CNS trypanosomiasis. Acta Trop 54:205–213
Pépin J, Ethier L, Kazadi C et al (1992) The impact of human immunodeficiency virus infection on the epidemiology and treatment of Trypanosoma brucei gambiense sleeping sickness in Nioki, Zaire. Am J Trop Med Hyg 47:133–140
Kennedy PGE (2008) The continuing problem of human African trypanosomiasis (sleeping sickness). Ann Neurol 64:116–126
Harper K, Ocampo P, Steiner B et al (2008) On the origin of the treponematoses: a phylogenetic approach. PLoS Negl Trop Dis 2:e148
Ehrlich P, Bertheim A (1911) Derivatives of oxyarylarsinic acids and process of making same. US Patent 986,148
Christiansen WG (1920) Hypophosporous acid preparation of arsphenamine. (3, 3-diamino-4, 4-dihydroxy-arseno-benzene dihydrochloride. J Am Chem Soc 42:2402–2405
Lloyd NC, Morgan HW, Nicholson BK et al (2005) The composition of Ehrlich's Salvarsan: resolution of a century-old debate. Angew Chem Int Ed 44:941–944
Pariser RJ (2008) Syphilis rules. Clin Dermatol 26:399–410
Anonymous (1911) Salvarsan, new indications. Cal State J Med 9:265–266
Kaufmann SHE (2008) Paul Ehrlich: founder of chemotherapy. Nat Rev Drug Discov 7:373
Kolmer J, Schamberg J (1912) Experimental studies on the administration of salvarsan by mouth to animals and man. J Exp Med 15:498–509
Fleming A, Florey HW, Bodenham DC et al (1944) Discussion on penicillin. Proc R Soc Med 37:101–112
Chain E, Florey HW (1944) Penicillin. Endeavour 3:3–14
Chain E, Florey HW, Gardner AD et al (1940) Penicillin as a chemotherapeutic agent. Lancet 2:226–228
Florey HW, Chain E (1945) Penicillin: demonstration of its value as a chemotherapeutic agent. Preliminary report of a new method. Med Rec (1866-1922) 158:217–219
Florey HW (1944) Penicillin: a survey. Br Med J 2:169–170
Heatley NG (1945) Administration of penicillin by mouth. Lancet 1:590–591
Ehrlich P, Karrer P, Georg Speyer H (1915) Arseno-metallic compounds. Ber Dtsch Chem Ges 48:1634–1644
Raiziss GW, Kremens A (1926) Arseno-bismuth compound and process of making same. US Patent 1,605,691
Stokes JH, Chambers SO (1927) Bismuth arsphenamine sulphonate. J Am Med Assoc 89:1500
Rayburn CR, Boyd TM (1931) The treatment of neurosyphilis - Observations on 393 patients over a period of five years. Am J Syph 15:168–184
World Health Organisation (1997) Weekly epidemiological record 72:97–100
Gunn H (1918) Amebiasis: its radical cure with combined emetin and salvarsan products. Cal State J Med 16:240–244
Fourneau E (1925) Relation between chemical constitution and therapeutic action. In: Union Internationale de chimie pure et appliquée (ed.) Comptes rendus de la sixième conférence internationale de la chimie, Bucarest
James DM (1949) The relation between the effect of certain therapeutic agents on infusoria and on pathogenic protozoa. Ann Trop Med Parasitol 43:164–173
David NA, Anderson HH, Koch DA et al (1932) Comparative toxicity and protozoacidal action of acetarsone, carbarsone and certain related quinquevalent arsenical compounds. Proc Soc Exp Biol Med 29:125–128
Chopra RN, Sen B, Sen G (1935) Amibiarson in the treatment of chronic intestinal amebiasis. Ind Med Gaz 70:324–328
Anonymous. (1971) Food additives. Carbarsone (not USP) in combination with bacitracin methylene disalicylate. Fed Regist 36:24001–24002
Schneider J, Dupoux R, Montezin G (1957) Traitement de l'amibiase intestinale par le diphetarsone-spiramycine (6 753 RP). Bull Soc Pathol Exot Filiales 50:600–606
Elsdondew R, Powell SP, Wilmot AJ (1957) Diphetarsone in the treatment of acute amoebic dysentery. J Trop Med Hyg 60:16–18
Schneider J, Biguet J, Machez J (1960) Treatment of oxyuriasis by diphetarsone-spiramycin and by diphetarsone. Therapie 15:648–654
Friedheim EAH (1949) A five day peroral treatment of yaws with stb, a new trivalent arsenical. Am J Trop Med Hyg 29(suppl 1):185
Anonyme (1953) New and nonofficial remedies; arsthinol. J Am Med Assoc 152:531
Abernathy CO, Liu YP, Longfellow D et al (1999) Arsenic: health effects, mechanisms of actions, and research issues. Environ Health Perspect 107:593–597
Stohrer G (1991) Arsenic: opportunity for risk assessment. Arch Toxicol 65:525–531
Cutler E, Bradford E (1878) Action of iron, cod liver oil and arsenic on globular richness of the blood. Am J Med Sci 75:74–84
Stockman R (1898) The action of arsenic on the bone-marrow and blood. J Physiol 23:376–382
Forkner C, Scott T (1931) Arsenic as a therapeutic agent in chronic myelogenous leukemia. J Am Med Assoc 97:3–5
Rontgen W (1896) On a new kind of rays. Science 3:227–231
Senn N (1903) Case of spleno-medullary leukemia successfully treated by the use of roentgen ray. Med Rec NY 63:281
Wang ZY (2001) Arsenic compounds as anticancer agents. Cancer Chemother Pharmacol 48(suppl 1):S72–S76
Sun HD, Li H, Ma L et al (1992) Treatment of acute promyelocytic leukemia by Ailing-1 therapy (in Chinese). Chin J Integr Trad Med West Med 12:170–172
Zhang P, Wang SY, Lu LH et al (1996) Arsenic trioxide-treated 72 cases of acute promyelocytic leukemia (in Chinese). Clin J Hematol 17:58–62
Lu DP, Qiu JY, Jiang B et al (2002) Tetra-arsenic tetra-sulfide for the treatment of acute promyelocytic leukemia: a pilot report. Blood 99:3136–3143
Soignet SL, Tong WP, Hirschfeld S et al (1999) Clinical study of an organic arsenical, melarsoprol, in patients with advanced leukemia. Cancer Chemother Pharmacol 44:417–421
Soignet SL, Maslak P, Wang ZG et al (1998) Complete remission after treatment of acute promyelocytic leukemia with arsenic trioxide. N Engl J Med 339:1341–1348
Warrell R, Soignet S, Maslak P et al (1998) Initial western study of arsenic trioxide (As2O3) in acute promyelocytic leukemia (APL). Proc Am Soc Clin Oncol 17:6a
Chen GQ, Zhu J, Shi XG et al (1996) In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML- RARα/PML proteins. Blood 88:1052–1061
Dai J, Weinberg RS, Waxman S et al (1999) Malignant cells can be sensitized to undergo growth inhibition and apoptosis by arsenic trioxide through modulation of the glutathione redox system. Blood 93:268–277
Jing Y, Dai J, Chalmers-Redman RME et al (1999) Arsenic trioxide selectively induces acute promyelocytic leukemia cell apoptosis via a hydrogen peroxide-dependent pathway. Blood 94:2102–2111
Schmidt A, Koppelt J, Neustadt M et al (2007) Mass spectrometric evidence for different complexes of peptides and proteins with arsenic (III), arsenic (V), copper (II), and zinc (II) species. Rapid Commun Mass Spectrom 21:153–163
Rousselot P, Labaume S, Marolleau JP et al (1999) Arsenic trioxide and melarsoprol induce apoptosis in plasma cell lines and in plasma cells from myeloma patients. Cancer Res 59:1041–1048
Wang ZG, Rivi R, Delva L et al (1998) Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML-RARalpha independent manner. Blood 92:1497–1504
Konig A, Wrazel L, Warrell RP et al (1997) Comparative activity of melarsoprol and arsenic trioxide in chronic B- cell leukemia lines. Blood 90:562–570
De Los SJ, Thomas G (2007) Anemia correction in malignancy management: threat or opportunity? Gynecol Oncol 105:517–529