Localization of the human Rh blood group gene structure to chromosome region 1p34.3–1p36.1 by in situ hybridization - Human Genetics
- ️Colin, Y.
- ️Fri Feb 01 1991
Summary
A cDNA clone, RhIXb (1384 bp), encoding the entire protein sequence of a human blood group Rh polypeptide has been used to map the Rh locus, by in situ hybridization, to the region p34.3–p36.1 of chromosome 1. Two other unrelated cDNA clones, pUCA2 (750bp) and pUCIII (1600 bp), isolated during the cloning procedure of the Rh cDNA were investigated simultaneously, and assigned to chromosome 3p21.1–3p22 (clone pUCA2) and to chromosome 22q12.1–22q13.1 (clone pUCIII).
Access this article
Subscribe and save
- Get 10 units per month
- Download Article/Chapter or eBook
- 1 Unit = 1 Article or 1 Chapter
- Cancel anytime
Buy Now
Price excludes VAT (USA)
Tax calculation will be finalised during checkout.
Instant access to the full article PDF.
Similar content being viewed by others
References
Avent ND, Ridgwell K, Mawby WJ, Tanner MJA, Anstee DJ, Kumpel B (1988) Protein-sequence studies on Rh-related polypeptides suggest the presence of at least two groups of proteins which associate in the human red cell membrane. Biochem J 256:1043–1046.
Blanchard D, Bloy C, Hermand P, Cartron JP, Saboori AM, Smith B, Agre P (1988) Two-dimensional iodopeptide mapping demonstrates that erythrocyte RhD, c and E polypeptides are structurally homologous but non identical. Blood 72:1424–1427.
Bloy C, Blanchard D, Dahr W, Beyreuther K, Salmon C, Cartron JP (1988) Determination of the N-terminal sequence of human red cell Rh (D) polypeptide and demonstration that the Rh (D), (c) and (E) antigens are carried by distinct polypeptide chains. Blood 72:661–666.
Bruns GAP, Sherman SL (1989) Report of the committee on the genetic constitution of chromosome 1. (10th International Workshop on Human Gene Mapping) Cytogenet Cell Genet 51:67–90.
Chérif-Zahar B, Bloy C, Le VanKim C, Blanchard D, Bailly P, Hermand P, Salmon C, Cartron JP, Colin Y (1990) Molecular cloning and protein structure of a human blood group Rh polypeptide. Proc Natl Acad Sci USA 87:6243–6247.
Clausen H, Hakomori SI (1989) ABH and related histo-blood group antigens. Immunochemical differences in carrier isotypes and their distribution. Vox Sang 56:1–20.
Dumanski JP, Carlbom E, Collins VP, Nordenskjöld M (1987) Deletion mapping of a locus on human chromosome 22 involved in the oncogenesis of meningioma. Proc Natl Acad Sci USA 84:9275–9279.
Kaplan JC, Emanuel BS (1989) Report of the committee on the genetic condition of chromosome 22. (10th International Workshop on Human Gene Mapping) Cytogenet Cell Genet 51: 372–383.
Mattei MG, Phillip N, Passage E, Moisan JP, Mandel JL, Mattei JF (1985) DNA probe localization at 18p11.3 band by in situ hybridization and identification of a small supernumerary chromosome. Hum Genet 69:268–271.
Miller YE, Daniels GL, Jones C, Palmer DK (1987) Identification of a cell-surface antigen produced by a gene on human chromosome 3 (cen-q22) and not expressed by Rh null cells. Am J Hum Genet 41:1061–1070.
Saboori AM, Smith B, Agree P (1988) Polymorphism in the Mr 32,000 Rh protein purified from Rh(D)-positive and -negative erythrocytes. Proc Natl Acad Sci USA 85:4042–4045.
Watkins W (1980) Biochemistry and genetics of the ABO, Lewis and P blood group systems. In: Harris H, Hischhorn K (eds) Advances in human genetics, vol 10. Plenum Press, New York, pp 1–36.
Author information
Authors and Affiliations
INSERM U.76, Institut National de Transfusion Sanguine, 6, rue Alexandre Cabanel, F-75015, Paris, France
B. Chérif-Zahar, C. Le Van Kim, P. Bailly, J. -P. Cartron & Y. Colin
INSERM U.242, Centre de Génétique Médicale, Hôpital d'Enfants de la Timone, F-13385, Marseille Cedex, France
M. G. Mattéi
Authors
- B. Chérif-Zahar
You can also search for this author inPubMed Google Scholar
- M. G. Mattéi
You can also search for this author inPubMed Google Scholar
- C. Le Van Kim
You can also search for this author inPubMed Google Scholar
- P. Bailly
You can also search for this author inPubMed Google Scholar
- J. -P. Cartron
You can also search for this author inPubMed Google Scholar
- Y. Colin
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
Chérif-Zahar, B., Mattéi, M.G., Le Van Kim, C. et al. Localization of the human Rh blood group gene structure to chromosome region 1p34.3–1p36.1 by in situ hybridization. Hum Genet 86, 398–400 (1991). https://doi.org/10.1007/BF00201843
Received: 22 June 1990
Revised: 08 August 1990
Issue Date: February 1991
DOI: https://doi.org/10.1007/BF00201843