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Electrophysiological actions of chlorimipramine on guinea-pig ventricular fibres - Cellular and Molecular Life Sciences

  • ️Rodriguez, S.
  • ️Thu Mar 01 1979

Summary

Chlorimipramine (CMI, 1×10−5M to 7×10−5M) decreased the amplitude, overshoot and rate of rise of ventricular action potentials and abolished the Ca-mediated action potentials elicited in guinea-pig papillary muscles. These results indicates that CMI inhibits the rise in sodium and calcium conductances during the cardiac action potential.

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Authors and Affiliations

  1. Department of Pharmacology, Medical School, Universidad Complutense, Madrid 3, Spain

    J. Tamargo & S. Rodriguez

Authors

  1. J. Tamargo

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  2. S. Rodriguez

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Tamargo, J., Rodriguez, S. Electrophysiological actions of chlorimipramine on guinea-pig ventricular fibres. Experientia 35, 366–367 (1979). https://doi.org/10.1007/BF01964356

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  • Published: 01 March 1979

  • Issue Date: March 1979

  • DOI: https://doi.org/10.1007/BF01964356

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