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Analysis of a case of mutagen specificity inNeurospora crassa - Molecular Genetics and Genomics

  • ️Ramsay, D.
  • ️Tue Dec 01 1970

Summary

Weak doses of DEB given before or after a moderately high dose act as “booster” for the production of adenine-reversions. Fractionation of a moderate or high dose into a succession of weak ones yields a dose-effect curve that lies above the linear curve expected for additivity of the fractions but below that found after continuous exposure. The results lend support to the view that DEB, in addition to producing potential adenine-reversions in DNA, promotes their realization by its effect on some cellular process or processes, and that this is the cause of the steep dose-response to continuous exposure.

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References

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Authors and Affiliations

  1. Institute of Animal Genetics, Edinburgh

    C. Auerbach & D. Ramsay

Authors

  1. C. Auerbach

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  2. D. Ramsay

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Additional information

Communicated by H. Böhme

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Cite this article

Auerbach, C., Ramsay, D. Analysis of a case of mutagen specificity inNeurospora crassa . Molec. Gen. Genet. 109, 285–291 (1970). https://doi.org/10.1007/BF00267697

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  • Received: 26 October 1970

  • Published: 01 December 1970

  • Issue Date: December 1970

  • DOI: https://doi.org/10.1007/BF00267697

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