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Phospholipase D: a lipid centric review - Cellular and Molecular Life Sciences

  • ️Frohman, M. A.
  • ️Wed Sep 07 2005

Abstract.

Phospholipase D (PLD) hydrolyzes the phosphodiester bond of the glycerolipid phosphatidylcholine, resulting in the production of phosphatidic acid and free choline. Phosphatidic acid is widely considered to be the intracellular lipid mediator of many of the biological functions attributed to PLD. However, phosphatidic acid is a tightly regulated lipid in cells and can be converted to other potentially bioactive lipids, including diacylglycerol and lysophosphatidic acid. PLD activities have been described in multiple organisms, including plants, mammals, bacteria and yeast. In mammalian systems, PLD activity regulates the actin cytoskeleton, vesicle trafficking for secretion and endocytosis, and receptor signaling. PLD is in turn regulated by phosphatidylinositol-4,5-bisphosphate, protein kinase C and ADP Ribosylation Factor and Rho family GTPases. This review focuses on the lipid precursors and products of mammalian PLD metabolism, especially phosphatidic acid and the roles this lipid performs in the mediation of the functions of PLD.

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Authors and Affiliations

  1. Department of Pharmacology and the Center for Developmental Genetics, University Medical Center at Stony Brook, 495 CMM, Stony Brook, New York, 11794-5140, USA

    G. M. Jenkins & M. A. Frohman

Authors

  1. G. M. Jenkins

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  2. M. A. Frohman

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Correspondence to G. M. Jenkins.

Additional information

Received 9 May 2005; received after revision 9 June 2005; accepted 30 June 2005

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Cite this article

Jenkins, G.M., Frohman, M.A. Phospholipase D: a lipid centric review. Cell. Mol. Life Sci. 62, 2305–2316 (2005). https://doi.org/10.1007/s00018-005-5195-z

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  • Published: 07 September 2005

  • Issue Date: October 2005

  • DOI: https://doi.org/10.1007/s00018-005-5195-z

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