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Mechanisms of voltage-gated ion channel regulation: from gene expression to localization - Cellular and Molecular Life Sciences

  • ️Garcia, M. L.
  • ️Mon Apr 14 2008

Abstract.

The ion channel milieu present in a neuron in large part determines the inherent excitability of a given cell and is responsible for the translation of sensory transduction and synaptic input to axonal output. Intrinsic excitability is a dynamic process subject to multiple levels of regulation from channel gene expression to post-translational modifications that influence channel activity. The goal of this review is to provide an overview of some of the mechanisms by which channels can be modified in order to influence neuronal output. We focus on four levels of regulation: channel gene transcription, alternative splicing of channel transcripts, post-translational modifications that alter channel kinetics (phosphorylation), and subcellular localization and trafficking of channel proteins.

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Authors and Affiliations

  1. Division of Biological Sciences, University of Missouri-Columbia, Columbia, Missouri, 65211, USA

    D. J. Schulz, S. Temporal, D. M. Barry & M. L. Garcia

Authors

  1. D. J. Schulz

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  2. S. Temporal

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  3. D. M. Barry

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  4. M. L. Garcia

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Corresponding author

Correspondence to D. J. Schulz.

Additional information

Received 1 February 2008; received after revision 28 February 2008; accepted 3 March 2008

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Cite this article

Schulz, D.J., Temporal, S., Barry, D.M. et al. Mechanisms of voltage-gated ion channel regulation: from gene expression to localization. Cell. Mol. Life Sci. 65, 2215–2231 (2008). https://doi.org/10.1007/s00018-008-8060-z

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  • Published: 14 April 2008

  • Issue Date: July 2008

  • DOI: https://doi.org/10.1007/s00018-008-8060-z

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