Nutritional hypophosphatemic rickets secondary to Neocate® use - Osteoporosis International

GI:

Gastrointestinal

FDA:

Food and Drug Administration

GERD:

Gastroesophageal reflux disease

G-Tube:

Gastrostomy tube

ALP:

Alkaline phosphatase

TRP:

Tubular reabsorption of phosphate

EoE:

Eosinophilic esophagitis

SFED:

Six food elimination diet

IV:

Intravenous

PPI:

Proton pump inhibitors

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Authors and Affiliations

1. Center For Endocrinology, Diabetes and Metabolism, Division of Pediatrics, Children’s Hospital Los Angeles (CHLA), 4650 Sunset Blvd, # 61, Los Angeles, CA, 90027, USA

   S. Akhtar Ali & P. Pitukcheewanont

2. Keck School of Medicine, University of Southern California, Los Angeles, CA, USA

   A. Mathalikunnel

3. Division of Gastroenterology, Hepatology and Nutrition, CHLA, Los Angeles, CA, USA

   V. Bhardwaj

4. Division of Clinical Immunology and Allergy, CHLA, Los Angeles, CA, USA

   M. Braskett

Corresponding author

Correspondence to P. Pitukcheewanont.

Conflicts of interest

None.

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Table of Contents Summary: We describe two patients exclusively fed with Neocate® who developed hypophosphatemic rickets. Both courses were complicated by hypocalcemia following intervention, highlighting the need for careful management in affected individuals.