link.springer.com

Vitamin D receptor genotypes are not associated with clinical response to calcipotriol in Korean psoriasis patients - Archives of Dermatological Research

  • ️Youn, Jai-Il
  • ️Tue Feb 26 2002

Abstract.

Conflicting results have been reported on the association between BsmI restriction fragment length polymorphism (RFLP) at the vitamin D receptor gene (VDR) locus and the clinical response of psoriasis patients to calcitriol or calcipotriol therapy. We evaluated RFLPs of the VDR gene by analyzing the restriction pattern of polymerase chain reaction products in 55 Korean psoriasis patients receiving topical calcipotriol therapy, and evaluated the clinical response. Of the 55 patients, 43 completed the 8-week treatment protocol, and the response was evaluated as excellent in 9 patients, good in 20, and poor in 14. Thus, in our 43 patients BsmI and ApaI polymorphism in the VDR gene did not correlate with response to calcipotriol. The marked predominance of the b allele in the Korean population precludes the possibility that BsmI polymorphism is associated with clinical response to calcipotriol. The pattern of prevalence of the VDR genotypes in the Korean population is very different from that in Western populations. There were no differences in VDR genotype between controls and psoriasis patients at the BsmI site, but there were significant difference in terms of ApaI RFLP as previously reported. In conclusion, polymorphism analysis of the VDR gene with BsmI and ApaI restriction enzymes in psoriasis patients was not helpful in predicting clinical response to calcipotriol.

Access this article

Log in via an institution

Subscribe and save

  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea

    Dong-Youn Lee, Byung-Soon Park, Kwang-Hyun Cho & Jai-Il Youn

  2. Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, 28 Yongon-Dong Chongno-Gu, Seoul 110-799, Korea

    Kyung-Ho Choi, Ju-Hong Jeon & In-Gyu Kim

  3. Department of Pathology, Chung-Ang University College of Medicine, Seoul, Korea

    Kye Song

Authors

  1. Dong-Youn Lee

    You can also search for this author inPubMed Google Scholar

  2. Byung-Soon Park

    You can also search for this author inPubMed Google Scholar

  3. Kyung-Ho Choi

    You can also search for this author inPubMed Google Scholar

  4. Ju-Hong Jeon

    You can also search for this author inPubMed Google Scholar

  5. Kwang-Hyun Cho

    You can also search for this author inPubMed Google Scholar

  6. Kye Song

    You can also search for this author inPubMed Google Scholar

  7. In-Gyu Kim

    You can also search for this author inPubMed Google Scholar

  8. Jai-Il Youn

    You can also search for this author inPubMed Google Scholar

Additional information

Electronic Publication

About this article

Cite this article

Lee, DY., Park, BS., Choi, KH. et al. Vitamin D receptor genotypes are not associated with clinical response to calcipotriol in Korean psoriasis patients. Arch Dermatol Res 294, 1–5 (2002). https://doi.org/10.1007/s00403-002-0293-3

Download citation

  • Received: 21 June 2001

  • Revised: 16 September 2001

  • Accepted: 03 January 2002

  • Published: 26 February 2002

  • Issue Date: March 2002

  • DOI: https://doi.org/10.1007/s00403-002-0293-3